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Immunomodulatory effects of the polysaccharide from on RAW264.7 macrophage cells.

作者信息

Liu Zhidong, Liu Zhifang, Li Laihao, Zhang Junjie, Zhao Qiancheng, Lin Na, Zhong Wenzhu, Jiang Mei

机构信息

East China Sea Fishery Research Institute Chinese Academy of Fishery Sciences Shanghai China.

South China Sea Fishery Research Institute Chinese Academy of Fishery Sciences Guangzhou China.

出版信息

Food Sci Nutr. 2022 Jan 25;10(4):1093-1102. doi: 10.1002/fsn3.2735. eCollection 2022 Apr.

DOI:10.1002/fsn3.2735
PMID:35432971
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9007286/
Abstract

This study aimed to evaluate the immunomodulatory effect of the polysaccharide from (SCP-1-1) in RAW264.7 cells. SCP-1-1 with a molecular weight of 440.0 kDa consisted of glucose and mannose. The immunomodulatory assay results showed that SCP-1-1 could significantly enhance phagocytic ability, NO production, and some cytokines (TNF-α, IL-6, and IL-1β) secretion of RAW264.7 cell in a dose-dependent manner. Western blot analysis results demonstrated that SCP-1-1 could regulate the expression levels of the key proteins in the signaling pathways of RAW264.7 cell and might associated with NF-κβ and PI3K signaling pathway. These findings could contribute to elucidate the immunomodulatory activities of the polysaccharide from .

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f79/9007286/9f44274370ba/FSN3-10-1093-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f79/9007286/613db1f770bd/FSN3-10-1093-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f79/9007286/3dbfaee2ca62/FSN3-10-1093-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f79/9007286/3258eb36b199/FSN3-10-1093-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f79/9007286/52f32f563f78/FSN3-10-1093-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f79/9007286/e2832ca2af86/FSN3-10-1093-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f79/9007286/be813e197bdf/FSN3-10-1093-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f79/9007286/bbefc817881a/FSN3-10-1093-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f79/9007286/4a5aa167950f/FSN3-10-1093-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f79/9007286/3f3eeed303cb/FSN3-10-1093-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f79/9007286/9f44274370ba/FSN3-10-1093-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f79/9007286/613db1f770bd/FSN3-10-1093-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f79/9007286/3dbfaee2ca62/FSN3-10-1093-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f79/9007286/3258eb36b199/FSN3-10-1093-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f79/9007286/52f32f563f78/FSN3-10-1093-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f79/9007286/e2832ca2af86/FSN3-10-1093-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f79/9007286/be813e197bdf/FSN3-10-1093-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f79/9007286/bbefc817881a/FSN3-10-1093-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f79/9007286/4a5aa167950f/FSN3-10-1093-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f79/9007286/3f3eeed303cb/FSN3-10-1093-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f79/9007286/9f44274370ba/FSN3-10-1093-g006.jpg

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引用本文的文献

[1]
Anti-Inflammatory and Immunomodulatory Properties of a Crude Polysaccharide Derived from Green Seaweed : Computational and Experimental Evidences.

Mar Drugs. 2024-2-11

[2]
A novel heteropolysaccharide isolated from custard apple pulp and its immunomodulatory activity in mouse macrophages and dendritic cells.

Heliyon. 2023-7-23

[3]
Thioredoxin A of Streptococcus suis Serotype 2 Contributes to Virulence by Inhibiting the Expression of Pentraxin 3 to Promote Survival Within Macrophages.

J Microbiol. 2023-4

[4]
Three-phase extraction of polysaccharide from : Process optimization, structural characterization and bioactivities.

Front Immunol. 2022

[5]
Piperine Derived from L. Inhibits LPS-Induced Inflammatory through the MAPK and NF-κB Signalling Pathways in RAW264.7 Cells.

Foods. 2022-9-26

[6]
The Main Structural Unit Elucidation and Immunomodulatory Activity In Vitro of a Selenium-Enriched Polysaccharide Produced by .

Molecules. 2022-4-18

本文引用的文献

[1]
Structural characterization and mechanisms of macrophage immunomodulatory activity of a pectic polysaccharide from Cucurbita moschata Duch.

Carbohydr Polym. 2021-10-1

[2]
Structural characterization and anti-inflammatory activity of a polysaccharide from the lignified okra.

Carbohydr Polym. 2021-8-1

[3]
Fractionation, structural characteristics and immunomodulatory activity of polysaccharide fractions from asparagus (Asparagus officinalis L.) skin.

Carbohydr Polym. 2021-3-15

[4]
Isolation, purification, structure and antioxidant activity of polysaccharide from pinecones of Pinus koraiensis.

Carbohydr Polym. 2021-1-1

[5]
Hypolipidemic and anti-atherogenic activities of crude polysaccharides from abalone viscera.

Food Sci Nutr. 2020-4-20

[6]
Structural Features of Three Hetero-Galacturonans from Fruits and Their in Vitro Immunomodulatory Effects.

Polymers (Basel). 2020-3-8

[7]
Structural characterization, antioxidant and immunomodulatory activities of a neutral polysaccharide from Cordyceps militaris cultivated on hull-less barley.

Carbohydr Polym. 2020-2-10

[8]
A novel polysaccharide from the roots of Millettia Speciosa Champ: preparation, structural characterization and immunomodulatory activity.

Int J Biol Macromol. 2019-12-28

[9]
Structural characterization and immunomodulatory activity of a novel polysaccharide from Pueraria lobata (Willd.) Ohwi root.

Int J Biol Macromol. 2020-7-1

[10]
A mild and efficient extraction method for polysaccharides from Sinonovacula constricta and study of their structural characteristic and antioxidant activities.

Int J Biol Macromol. 2019-10-31

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