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[具体来源]多糖对RAW264.7巨噬细胞的免疫调节作用

Immunomodulatory effects of the polysaccharide from on RAW264.7 macrophage cells.

作者信息

Liu Zhidong, Liu Zhifang, Li Laihao, Zhang Junjie, Zhao Qiancheng, Lin Na, Zhong Wenzhu, Jiang Mei

机构信息

East China Sea Fishery Research Institute Chinese Academy of Fishery Sciences Shanghai China.

South China Sea Fishery Research Institute Chinese Academy of Fishery Sciences Guangzhou China.

出版信息

Food Sci Nutr. 2022 Jan 25;10(4):1093-1102. doi: 10.1002/fsn3.2735. eCollection 2022 Apr.

DOI:10.1002/fsn3.2735
PMID:35432971
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9007286/
Abstract

This study aimed to evaluate the immunomodulatory effect of the polysaccharide from (SCP-1-1) in RAW264.7 cells. SCP-1-1 with a molecular weight of 440.0 kDa consisted of glucose and mannose. The immunomodulatory assay results showed that SCP-1-1 could significantly enhance phagocytic ability, NO production, and some cytokines (TNF-α, IL-6, and IL-1β) secretion of RAW264.7 cell in a dose-dependent manner. Western blot analysis results demonstrated that SCP-1-1 could regulate the expression levels of the key proteins in the signaling pathways of RAW264.7 cell and might associated with NF-κβ and PI3K signaling pathway. These findings could contribute to elucidate the immunomodulatory activities of the polysaccharide from .

摘要

本研究旨在评估[具体来源]的多糖（SCP-1-1）对RAW264.7细胞的免疫调节作用。分子量为440.0 kDa的SCP-1-1由葡萄糖和甘露糖组成。免疫调节测定结果表明，SCP-1-1能以剂量依赖性方式显著增强RAW264.7细胞的吞噬能力、一氧化氮（NO）生成以及某些细胞因子（肿瘤坏死因子-α、白细胞介素-6和白细胞介素-1β）的分泌。蛋白质免疫印迹分析结果表明，SCP-1-1可调节RAW264.7细胞信号通路中关键蛋白的表达水平，可能与核因子κB（NF-κβ）和磷脂酰肌醇-3激酶（PI3K）信号通路有关。这些发现有助于阐明[具体来源]多糖的免疫调节活性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f79/9007286/9f44274370ba/FSN3-10-1093-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f79/9007286/613db1f770bd/FSN3-10-1093-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f79/9007286/3dbfaee2ca62/FSN3-10-1093-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f79/9007286/3258eb36b199/FSN3-10-1093-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f79/9007286/52f32f563f78/FSN3-10-1093-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f79/9007286/e2832ca2af86/FSN3-10-1093-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f79/9007286/be813e197bdf/FSN3-10-1093-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f79/9007286/bbefc817881a/FSN3-10-1093-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f79/9007286/4a5aa167950f/FSN3-10-1093-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f79/9007286/3f3eeed303cb/FSN3-10-1093-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f79/9007286/9f44274370ba/FSN3-10-1093-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f79/9007286/613db1f770bd/FSN3-10-1093-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f79/9007286/3dbfaee2ca62/FSN3-10-1093-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f79/9007286/3258eb36b199/FSN3-10-1093-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f79/9007286/52f32f563f78/FSN3-10-1093-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f79/9007286/e2832ca2af86/FSN3-10-1093-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f79/9007286/be813e197bdf/FSN3-10-1093-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f79/9007286/bbefc817881a/FSN3-10-1093-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f79/9007286/4a5aa167950f/FSN3-10-1093-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f79/9007286/3f3eeed303cb/FSN3-10-1093-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f79/9007286/9f44274370ba/FSN3-10-1093-g006.jpg

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