Liu Binxiong, Jia Zhen, Li Changcheng, Chen Jinquan, Fang Ting
College of Food Science Fujian Agriculture and Forestry University Fuzhou China.
Engineering Research Center of Ministry of Education: Fujian-Taiwan Featured Marine Food Processing and Nutritional Health Fuzhou China.
Food Sci Nutr. 2020 Apr 20;8(5):2524-2534. doi: 10.1002/fsn3.1548. eCollection 2020 May.
This study was performed to evaluate the hypolipidemic and anti-atherogenic activities of the crude polysaccharides extracted from abalone viscera (AVCP). The major functional groups of purified polysaccharides were analyzed by infrared spectroscopy (IR). Male Kunming mice (SPF) were divided into six groups and were treated with normal diet or high-fat diet with AVCP or Xuezhikang (hypotensive drug) for 5 weeks. Physicochemnical analysis of AVCP showed the presence of 60.4% polysaccharides, 17.9% protein, 6.0% fat and 10.9% moisture. The IR analysis of AVP showed the presence of functional groups of sugar moiety and sulfate groups. The results demonstrated that AVCP not only led to significant reduction of total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and increase of high-density lipoprotein cholesterol (HDL-C) in plasma, but also to significant increments of malondialdehyde (MDA) and superoxide dismutase (SOD) activities. However, AVCP played no role in mice weight. Furthermore, the results of the photomicrograph of liver tissue showed that AVCP reduced lipid droplets and prevented the disordered structure of the liver. The results suggested that AVCP exhibited significantly hypolipidemic and anti-atherogenic activities.
本研究旨在评估从鲍鱼内脏中提取的粗多糖（AVCP）的降血脂和抗动脉粥样硬化活性。通过红外光谱（IR）分析纯化多糖的主要官能团。将雄性昆明小鼠（SPF）分为六组，分别用正常饮食或高脂饮食加AVCP或血脂康（降压药）处理5周。AVCP的理化分析表明，其含有60.4%的多糖、17.9%的蛋白质、6.0%的脂肪和10.9%的水分。AVP的IR分析表明存在糖部分和硫酸根的官能团。结果表明，AVCP不仅能显著降低血浆中总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C），并提高高密度脂蛋白胆固醇（HDL-C），还能显著提高丙二醛（MDA）和超氧化物歧化酶（SOD）的活性。然而，AVCP对小鼠体重没有影响。此外，肝组织显微照片结果显示，AVCP减少了脂滴并防止了肝脏结构紊乱。结果表明，AVCP具有显著的降血脂和抗动脉粥样硬化活性。
