Department of Radiation Oncology, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Republic of Korea.
Department of Radiation Oncology, Seoul National University Hospital, Seoul, Republic of Korea.
J Appl Clin Med Phys. 2022 Jun;23(6):e13615. doi: 10.1002/acm2.13615. Epub 2022 Apr 18.
This study aims to investigate a star shot analysis using a three-dimensional (3D) gel dosimeter for the imaging and radiation isocenter verification of a magnetic resonance linear accelerator (MR-Linac).
A mixture of methacrylic acid, gelatin, and tetrakis (hydroxymethyl) phosphonium chloride, called MAGAT gel, was fabricated. One MAGAT gel for each Linac and MR-Linac was irradiated under six gantry angles. A 6 MV photon beam of Linac and a 6 MV flattening filter free beam of MR-Linac were delivered to two MAGAT gels and EBT3 films. MR images were acquired by MR-Linac with a clinical sequence (i.e., TrueFISP). The 3D star shot analysis for seven consecutive slices of the MR images with TrueFISP was performed. The 2D star shot analysis for the central plane of the gel was compared to the results from the EBT3 films. The radius of isocircle (IC ) and the distance between the center of the circle and the center marked on the image (IC ) were evaluated.
For MR-Linac with MAGAT gel measurements, IC at the central plane was 0.46 mm for TrueFISP. Compared to EBT3 film measurements, the differences in IC and IC for both Linac and MR-Linac were within 0.11 and 0.13 mm, respectively. For the 3D analysis, seven consecutive slices of TrueFISP images were analyzed and the maximum radii of isocircles (IC ) were 0.18 mm for Linac and 0.73 mm for MR-Linac. The tilting angles of radiation axis were 0.31° for Linac and 0.10° for MR-Linac.
The accuracy of 3D star shot analysis using MAGAT gel was comparable to that of EBT3 film, having a capability for integrated analysis for imaging isocenter and radiation isocenter. 3D star shot analysis using MAGAT gel can provide 3D information of radiation isocenter, suggesting a quantitative extent of gantry-tilting.
本研究旨在利用三维(3D)凝胶剂量计对磁共振直线加速器(MR-Linac)的成像和辐射等中心进行星爆分析。
制备了一种称为 MAGAT 凝胶的甲基丙烯酸、明胶和四羟甲基氯化磷混合物。每个直线加速器和 MR-Linac 各用一个 MAGAT 凝胶,在六个旋转角度下进行照射。直线加速器的 6MV 光子束和 MR-Linac 的 6MV 无均整滤过自由束分别输送到两个 MAGAT 凝胶和 EBT3 胶片。MR 图像由具有临床序列(即 TrueFISP)的 MR-Linac 采集。对具有 TrueFISP 的七个连续 MR 图像切片进行了 3D 星爆分析。将凝胶中央平面的 2D 星爆分析与 EBT3 胶片的结果进行了比较。评估了等圆(IC)的半径和圆的中心与图像上标记的中心(IC)之间的距离。
对于 MR-Linac 与 MAGAT 凝胶测量,TrueFISP 中心平面的 IC 为 0.46mm。与 EBT3 胶片测量相比,直线加速器和 MR-Linac 的 IC 和 IC 差异分别在 0.11 和 0.13mm 以内。对于 3D 分析,对 TrueFISP 图像的七个连续切片进行了分析,最大等圆半径(IC)为直线加速器 0.18mm,MR-Linac 0.73mm。直线加速器的辐射轴倾斜角为 0.31°,MR-Linac 的倾斜角为 0.10°。
使用 MAGAT 凝胶的 3D 星爆分析的准确性与 EBT3 胶片相当,具有成像等中心和辐射等中心的综合分析能力。MAGAT 凝胶的 3D 星爆分析可以提供辐射等中心的 3D 信息,提示了转架倾斜的定量程度。