Zhu Zhongqiang, Gao Qiang, Long Ziyue, Huo Qiuyi, Ge Yifan, Vianney Ntakirutimana, Daliko Nishimwe Anodine, Meng Yongchun, Qu Jia, Chen Hao, Wang Bailiang
School of Ophthalmology & Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, China.
Central Laboratory, Yantai Affiliated Hospital of Binzhou Medical University, 717 Jinbu Street, Yantai, Shandong, 264100, China.
Bioact Mater. 2021 Feb 5;6(8):2546-2556. doi: 10.1016/j.bioactmat.2021.01.025. eCollection 2021 Aug.
Implanted biomaterials such as medical catheters are prone to be adhered by proteins, platelets and bacteria due to their surface hydrophobicity characteristics, and then induce related infections and thrombosis. Hence, the development of a versatile strategy to endow surfaces with antibacterial and antifouling functions is particularly significant for blood-contacting materials. In this work, CuSO/HO was used to trigger polydopamine (PDA) and poly-(sulfobetaine methacrylate) (PSBMA) co-deposition process to endow polyurethane (PU) antibacterial and antifouling surface (PU/PDA(Cu)/PSBMA). The zwitterions contained in the PU/PDA(Cu)/PSBMA coating can significantly improve surface wettability to reduce protein adsorption, thereby improving its blood compatibility. In addition, the copper ions released from the metal-phenolic networks (MPNs) imparted them more than 90% antibacterial activity against and . Notably, PU/PDA(Cu)/PSBMA also exhibits excellent performance mouse catheter-related infections models. Thus, the PU/PDA(Cu)/PSBMA has great application potential for developing multifunctional surface coatings for blood-contacting materials so as to improve antibacterial and anticoagulant properties.
诸如医用导管之类的植入生物材料由于其表面疏水性特征，容易被蛋白质、血小板和细菌粘附，进而引发相关感染和血栓形成。因此，开发一种赋予表面抗菌和抗污功能的通用策略对于血液接触材料而言尤为重要。在这项工作中，使用硫酸铜/过氧化氢引发聚多巴胺（PDA）和聚（甲基丙烯酸磺酸甜菜碱）（PSBMA）的共沉积过程，以赋予聚氨酯（PU）抗菌和抗污表面（PU/PDA（Cu）/PSBMA）。PU/PDA（Cu）/PSBMA涂层中含有的两性离子可显著改善表面润湿性以减少蛋白质吸附，从而提高其血液相容性。此外，从金属-酚醛网络（MPNs）释放的铜离子赋予它们对[具体细菌1]和[具体细菌2]超过90%的抗菌活性。值得注意的是，PU/PDA（Cu）/PSBMA在小鼠导管相关感染模型中也表现出优异性能。因此，PU/PDA（Cu）/PSBMA在开发用于血液接触材料的多功能表面涂层以改善抗菌和抗凝性能方面具有巨大的应用潜力。
