Clin Lab. 2022 Apr 1;68(4). doi: 10.7754/Clin.Lab.2021.210746.
In this study, we investigated the predictive value of routine coagulation parameters including D-dimer, Prothrombin Time (PT), International Normalized Ratio (INR), activated Partial Thromboplastin Time (aPTT) and Complete Blood Count (CBC) test parameters in children with COVID-19 infection.
Retrospective and observational study carried out in Abuzar Hospital, Ahvaz Jundishapur University of Medical Sciences (Ahvaz, Iran) included COVID-19 patients.
Deceased patients (n = 5) compared to alive patients (n = 76) showed higher RDW (p = 0.005), PT (p = 0.005), INR (p = 0.004), PTT (p = 0.009), platelet count (p < 0.001), PLR (p < 0.001), and hospitalization time (p < 0.001). The area under the curve (AUC) of RDW was 0.85 (95% CI 0.75 - 0.96) which indicates its high power for mortality prediction in hospitalized children with COVID-19. We did not find significant differences in parameters in comparison between different severities.
To our knowledge, our study is one of the few studies to evaluate routine coagulation tests and the CBC test parameters predictive value in children with COVID-19. RDW has the most power to predict the mortality of children with COVID-19, followed by PT, INR, aPTT, platelet count, PLR, and hospitalization time have a high power to predict the risk of death in patients.
在这项研究中，我们调查了包括 D-二聚体、凝血酶原时间 (PT)、国际标准化比值 (INR)、活化部分凝血活酶时间 (aPTT) 和全血细胞计数 (CBC) 测试参数在内的常规凝血参数在 COVID-19 感染儿童中的预测价值。
这项回顾性和观察性研究在阿瓦兹贾迪德舒尔大学医学科学阿布扎尔医院（伊朗阿瓦兹）进行，纳入了 COVID-19 患者。
与存活患者（n = 76）相比，死亡患者（n = 5）的红细胞分布宽度 (RDW) 更高（p = 0.005）、PT（p = 0.005）、INR（p = 0.004）、aPTT（p = 0.009）、血小板计数（p < 0.001）、PLR（p < 0.001）和住院时间（p < 0.001）。RDW 的曲线下面积（AUC）为 0.85（95%CI 0.75-0.96），表明其在预测 COVID-19 住院儿童死亡率方面具有较高的能力。我们没有发现不同严重程度之间参数存在显著差异。
据我们所知，我们的研究是少数评估 COVID-19 儿童常规凝血试验和 CBC 试验参数预测价值的研究之一。RDW 预测 COVID-19 儿童死亡率的能力最强，其次是 PT、INR、aPTT、血小板计数、PLR 和住院时间，对患者死亡风险具有较高的预测能力。
