Orrillo A Gastón, Furlan Ricardo L E
Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, CONICET, Suipacha 531, Rosario, S2002LRK, Argentina.
Angew Chem Int Ed Engl. 2022 Jun 27;61(26):e202201168. doi: 10.1002/anie.202201168. Epub 2022 May 17.
Sulfur has been important in dynamic covalent chemistry (DCC) since the beginning of the field. Mainly as part of disulfides and thioesters, dynamic sulfur-based bonds (DSBs) have a leading role in several remarkable reactions. Part of this success is due to the almost ideal properties of DSBs for the preparation of dynamic covalent systems, including high reactivity and good reversibility under mild aqueous conditions, the possibility of exploiting supramolecular interactions, access to isolable structures, and easy experimental control to turn the reaction on/off. DCC is currently witnessing an increase in the importance of DSBs. The chemical flexibility offered by DSBs opens the door to multiple applications. This Review presents an overview of all the DSBs used in DCC, their applications, and remarks on the interesting properties that they confer on dynamic chemical systems, especially those containing several DSBs.
自该领域起步以来，硫在动态共价化学（DCC）中一直扮演着重要角色。动态硫基键（DSB）主要作为二硫键和硫酯的一部分，在一些引人注目的反应中发挥着主导作用。这一成功部分归因于DSB对于制备动态共价体系几乎具有理想的性质，包括在温和的水性条件下具有高反应活性和良好的可逆性、利用超分子相互作用的可能性、获得可分离结构以及易于进行实验控制以开启/关闭反应。目前，DCC中DSB的重要性正在不断增加。DSB所提供的化学灵活性为多种应用打开了大门。本综述概述了DCC中使用的所有DSB、它们的应用，以及关于它们赋予动态化学体系（尤其是那些含有多个DSB的体系）的有趣性质的评论。
