青年人群中亲脂性持久性有机污染物的血浆浓度与葡萄糖内稳定状态。
Plasma concentrations of lipophilic persistent organic pollutants and glucose homeostasis in youth populations.
机构信息
Department of Preventative Medicine, University of Southern California, Los Angeles, CA, United States.
Department of Preventative Medicine, University of Southern California, Los Angeles, CA, United States.
出版信息
Environ Res. 2022 Sep;212(Pt B):113296. doi: 10.1016/j.envres.2022.113296. Epub 2022 Apr 18.
BACKGROUND
Exposure to lipophilic persistent organic pollutants (POPs) is ubiquitous. POPs are metabolic disrupting chemicals and are potentially diabetogenic.
METHODS
Using a multi-cohort study including overweight adolescents from the Study of Latino Adolescents at Risk (SOLAR, N = 301, 2001-2012) and young adults from the Southern California Children's Health Study (CHS, N = 135, 2014-2018), we examined associations of POPs and risk factors for type 2 diabetes. SOLAR participants underwent annual visits for a median of 2.2 years and CHS participants performed a single visit, during which a 2-h oral glucose tolerance test was performed. Linear mixed models were used to examine associations between plasma concentrations of POPs [4,4'-dichlorodiphenyldichloroethylene (4,4'-DDE), hexachlorobenzene (HCB), PCBs-153, 138, 118, 180 and PBDEs-154, 153, 100, 85, 47] and changes in glucose homeostasis across age and pubertal stage.
RESULTS
In SOLAR, exposure to HCB, PCB-118, and PBDE-153 was associated with dysregulated glucose metabolism. For example, each two-fold increase in HCB was associated with approximately 2 mg/dL higher glucose concentrations at 30 min (p = 0.001), 45 min (p = 0.0006), and 60 min (p = 0.03) post glucose challenge. Compared to individuals with low levels of PCB-118, individuals with high levels exhibited a 4.7 mg/dL (p = 0.02) higher glucose concentration at 15 min and a 3.6 mg/dL (p = 0.01) higher glucose concentration at 30 min. The effects observed with exposure to organochlorine compounds were independent of pubertal stages. PBDE-153 was associated with the development of dysregulated glucose metabolism beginning in late puberty. At Tanner stage 4, exposure to PBDE-153 was associated with a 12.7 mg/dL higher 60-min glucose concentration (p = 0.009) and a 16.1 mgdlhr higher glucose AUC (p = 0.01). These associations persisted at Tanner 5. In CHS, PBDE-153 and total PBDE were associated with similar increases in glucose concentrations.
CONCLUSION
Our results suggest that childhood exposure to lipophilic POPs is associated with dysregulated glucose metabolism.
背景
脂溶性持久性有机污染物 (POPs) 的暴露无处不在。POPs 是代谢干扰化学物质，可能具有致糖尿病作用。
方法
我们使用包括超重青少年的多队列研究（SOLAR，N=301，2001-2012 年）和来自南加州儿童健康研究（CHS，N=135，2014-2018 年）的年轻成年人的队列研究，检查了 POPs 与 2 型糖尿病风险因素之间的关联。SOLAR 参与者每年接受一次访视，中位随访时间为 2.2 年，CHS 参与者进行了一次访视，期间进行了 2 小时口服葡萄糖耐量试验。线性混合模型用于检查血浆中 POPs [4,4'-二氯二苯二氯乙烯 (4,4'-DDE)、六氯苯 (HCB)、多氯联苯-153、138、118、180 和多溴二苯醚-154、153、100、85、47] 浓度与年龄和青春期阶段之间葡萄糖稳态变化之间的关联。
结果
在 SOLAR 中，HCB、PCB-118 和 PBDE-153 的暴露与葡萄糖代谢失调有关。例如，HCB 每增加两倍，与葡萄糖负荷后 30 分钟（p=0.001）、45 分钟（p=0.0006）和 60 分钟（p=0.03）的葡萄糖浓度升高约 2mg/dL 相关。与低水平 PCB-118 的个体相比，高水平 PCB-118 的个体在 15 分钟时的葡萄糖浓度升高 4.7mg/dL（p=0.02），在 30 分钟时的葡萄糖浓度升高 3.6mg/dL（p=0.01）。观察到的与有机氯化合物暴露相关的影响与青春期阶段无关。PBDE-153 与青春期后期开始的葡萄糖代谢失调的发展有关。在 Tanner 阶段 4 时，暴露于 PBDE-153 与 60 分钟时升高 12.7mg/dL 的葡萄糖浓度（p=0.009）和升高 16.1mgdlhr 的葡萄糖 AUC（p=0.01）相关。这些关联在 Tanner 5 阶段仍然存在。在 CHS 中，PBDE-153 和总 PBDE 与葡萄糖浓度的类似升高有关。
结论
我们的结果表明，儿童时期接触脂溶性 POPs 与葡萄糖代谢失调有关。
Zotero 插件