Guangdong Provincial Engineering Technology Research Center of Marine Food, Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, College of Food Science and Technology, Guangdong Ocean University, Zhanjiang 524088, China.
Collaborative Innovation Center of Seafood Deep Processing, Dalian Polytechnic University, Dalian 116034, China.
Mar Drugs. 2022 Apr 1;20(4):252. doi: 10.3390/md20040252.
Excessive exposure of the skin to ultraviolet irradiation induces skin photoaging, which seriously deteriorates the barrier functions of skin tissue, and even causes skin damages and diseases. Recently, dietary supplements from marine sources have been found to be useful in modulating skin functions and can be used to alleviate photoaging. Herein, the low-molecular-weight hydrolysates with a photoaging-protection effect were prepared by enzymatic hydrolysis from Theragra chalcogramma (TCH), and the potential mechanism were subsequently explored. The results revealed that TCH desirably improved the barrier functions of photoaged skin and stimulated the deposition of ECM components Col I, Hyp, and HA in the dermal layer. Histologically, TCH reduced the epidermal hyperplasia and restored the impaired architectures in a dose-dependent manner. Meanwhile, the activity of matrix metalloproteinase-1 (MMP-1) in photoaging skin was inhibited, and the expression levels of elastin and fibrillin-1 were elevated accordingly after TCH administration, and the significant improvements were observed at high-dose level (p < 0.05). Taken together, the efficacy of TCH against skin photoaging is highly associated with the regulation on ECM metabolism and the repairing of damaged mechanical structure.
皮肤过度暴露于紫外线辐射会导致皮肤光老化，严重破坏皮肤组织的屏障功能，甚至导致皮肤损伤和疾病。最近，从海洋来源的膳食补充剂被发现对调节皮肤功能具有作用，并可用于缓解光老化。在此，通过酶解从智利竹䇲鱼（TCH）制备了具有光保护作用的低分子量水解产物，并随后探索了其潜在机制。结果表明，TCH 可改善光老化皮肤的屏障功能，并刺激真皮层中 ECM 成分 Col I、Hyp 和 HA 的沉积。组织学上，TCH 以剂量依赖的方式减少表皮增生并恢复受损的结构。同时，TCH 抑制了光老化皮肤中基质金属蛋白酶-1（MMP-1）的活性，并且弹性蛋白和原纤维蛋白-1的表达水平相应升高，在高剂量水平时观察到显著改善（p < 0.05）。综上所述，TCH 对皮肤光老化的功效与其对 ECM 代谢的调节和受损机械结构的修复密切相关。
