Huang Nai-Wei, Lin Jian-Hong, Jhan Jin-You, Hsu Bang-Gee, Chang Jui-Chih
Division of Cardiovascular Surgery, Department of Surgery, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 97002, Taiwan.
Division of Experimental Surgery, Department of Surgery, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 97002, Taiwan.
J Cardiovasc Dev Dis. 2022 Mar 31;9(4):105. doi: 10.3390/jcdd9040105.
Old age has been proven to be related to progressed arterial or aortic stiffness. Aortic stiffness is an independent predictor of all-cause and cardiovascular disease mortalities in patients who have undergone coronary artery bypass grafting (CABG) surgery. Higher serum concentrations of adipocyte fatty-acid-binding protein (A-FABP) could be considered a predictor of aortic stiffness in patients with hypertension or diabetes mellitus. This study aims to investigate the relationships between A-FABP and aortic stiffness in patients who have received CABG. A total of 84 CABG patients were enrolled in our study from September 2018 to May 2019. Serum A-FABP levels were determined using a commercial enzyme immunoassay. Carotid−femoral pulse wave velocity (cfPWV) > 10 m/s was defined as aortic stiffness. Of the 84 CABG patients, 28 (33.3%) with aortic stiffness had a higher average age; exhibited higher rates of diabetes; and had higher serum creatinine, C-reactive protein, and A-FABP levels compared to controls. Multivariable logistic regression revealed that serum A-FABP levels (odds ratio (OR) = 1.068, 95% confidence interval (CI) 1.017−1.121, p = 0.008) and age (OR = 1.204, 95% CI 1.067−1.359, p = 0.003) were independent predictors of aortic stiffness. Multivariable stepwise linear regression revealed significant positive correlations of age and A-FABP levels with cfPWV values. Serum A-FABP level is positively correlated with cfPWV values, and a high serum A-FABP level is associated with aortic stiffness in patients who have undergone CABG.
衰老已被证明与动脉或主动脉僵硬度进展有关。主动脉僵硬度是接受冠状动脉旁路移植术（CABG）的患者全因死亡率和心血管疾病死亡率的独立预测指标。较高的血清脂肪细胞脂肪酸结合蛋白（A-FABP）浓度可被视为高血压或糖尿病患者主动脉僵硬度的预测指标。本研究旨在探讨接受CABG的患者中A-FABP与主动脉僵硬度之间的关系。2018年9月至2019年5月，共有84例CABG患者纳入本研究。采用商业酶免疫测定法测定血清A-FABP水平。颈动脉-股动脉脉搏波速度（cfPWV）>10 m/s被定义为主动脉僵硬度。在84例CABG患者中，28例（33.3%）有主动脉僵硬度，其平均年龄较高；糖尿病发生率较高；与对照组相比，血清肌酐、C反应蛋白和A-FABP水平较高。多变量逻辑回归显示，血清A-FABP水平（比值比（OR）=1.068，95%置信区间（CI）1.017-1.121，p=0.008）和年龄（OR=1.204，95%CI 1.067-1.359，p=0.003）是主动脉僵硬度的独立预测指标。多变量逐步线性回归显示年龄和A-FABP水平与cfPWV值呈显著正相关。血清A-FABP水平与cfPWV值呈正相关，高血清A-FABP水平与接受CABG的患者主动脉僵硬度相关。
