Sung Cheng-Hao, Hsu Bang-Gee, Tasi Jen-Pi, Wang Chih-Hsien, Kuo Chiu-Huang
School of Medicine, Tzu-Chi University, Hualien, Taiwan.
Division of Nephrology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.
Int J Hypertens. 2021 Feb 6;2021:8849115. doi: 10.1155/2021/8849115. eCollection 2021.
Adipocyte fatty acid-binding protein (A-FABP) plays essential roles in lipolysis, insulin resistance, and atherosclerosis. This study aimed to evaluate the relationship between serum A-FABP levels and carotid-femoral pulse wave velocity (cfPWV) in peritoneal dialysis (PD) patients.
This study obtained fasting blood samples from 76 PD patients. A validated tonometry system was used to measure cfPWV. Patients with cfPWV values >10 m/s were classified into the high arterial stiffness group, whereas patients with values ≤10 m/s were classified into the low arterial stiffness group, according to the ESH-ESC 2013 guidelines. Serum A-FABP levels were measured using a commercial enzyme-linked immunosorbent assay kit.
Twenty-five (32.9%) of the 76 PD patients were classified in the high arterial stiffness group. Compared with the patients in the low arterial stiffness group, the high arterial stiffness group was older ( = 0.002) and had a longer PD vintage ( = 0.011), higher diastolic blood pressure (DBP, = 0.036), higher fasting glucose levels ( = 0.012), higher serum C reactive protein levels ( = 0.001), and higher serum A-FABP levels ( < 0.001). A multivariate logistic regression analysis of the factors significantly associated with central arterial stiffness revealed that A-FABP (odds ratio (OR): 1.165, 95% confidence interval (CI): 1.056-1.284, = 0.002), age (OR: 1.423, 95% CI: 1.153-1.757, = 0.001), PD vintage (OR: 1.049, 95% CI: 1.015-1.085, = 0.005), and DBP (OR: 1.152, 95% CI: 1.033-1.285, = 0.011) were independent predictors of central arterial stiffness in PD patients. Furthermore, serum A-FABP levels ( = 0.476, adjusted change: 0.197, < 0.001) were significantly positively correlated with cfPWV according to the multivariable forward stepwise linear regression analysis.
A-FABP levels are an independent marker of central arterial stiffness in PD patients.
脂肪细胞脂肪酸结合蛋白（A-FABP）在脂肪分解、胰岛素抵抗和动脉粥样硬化中起重要作用。本研究旨在评估腹膜透析（PD）患者血清A-FABP水平与颈股脉搏波速度（cfPWV）之间的关系。
本研究采集了76例PD患者的空腹血样。使用经过验证的眼压测量系统测量cfPWV。根据欧洲高血压学会（ESH）和欧洲心脏病学会（ESC）2013年指南，cfPWV值>10 m/s的患者被分为高动脉僵硬度组，而cfPWV值≤10 m/s的患者被分为低动脉僵硬度组。使用商用酶联免疫吸附测定试剂盒测量血清A-FABP水平。
76例PD患者中有25例（32.9%）被归类为高动脉僵硬度组。与低动脉僵硬度组患者相比，高动脉僵硬度组患者年龄更大（P = 0.002），腹膜透析病程更长（P = 0.011），舒张压（DBP）更高（P = 0.036），空腹血糖水平更高（P = 0.012），血清C反应蛋白水平更高（P = 0.001），血清A-FABP水平更高（P < 0.001）。对与中心动脉僵硬度显著相关的因素进行多变量逻辑回归分析显示，A-FABP（比值比（OR）：1.165，95%置信区间（CI）：1.056 - 1.284，P = 0.002）、年龄（OR：1.423，95%CI：1.153 - 1.757，P = 0.001）、腹膜透析病程（OR：1.049，95%CI：1.015 - 1.085，P = 0.005）和DBP（OR：1.152，95%CI：1.033 - 1.285，P = 0.011）是PD患者中心动脉僵硬度的独立预测因素。此外，根据多变量向前逐步线性回归分析，血清A-FABP水平（P = 0.476，调整R²变化：0.197，P < 0.001）与cfPWV显著正相关。
A-FABP水平是PD患者中心动脉僵硬度的独立标志物。
