腹膜透析患者脂肪细胞脂肪酸结合蛋白水平与中心动脉僵硬度之间的正相关关系。

Positive Associations between Adipocyte Fatty Acid-Binding Protein Level and Central Arterial Stiffness in Peritoneal Dialysis Patients.

作者信息

Sung Cheng-Hao, Hsu Bang-Gee, Tasi Jen-Pi, Wang Chih-Hsien, Kuo Chiu-Huang

机构信息

School of Medicine, Tzu-Chi University, Hualien, Taiwan.

Division of Nephrology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.

出版信息

Int J Hypertens. 2021 Feb 6;2021:8849115. doi: 10.1155/2021/8849115. eCollection 2021.

DOI:10.1155/2021/8849115

PMID:33628486

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7884152/

Abstract

BACKGROUND

Adipocyte fatty acid-binding protein (A-FABP) plays essential roles in lipolysis, insulin resistance, and atherosclerosis. This study aimed to evaluate the relationship between serum A-FABP levels and carotid-femoral pulse wave velocity (cfPWV) in peritoneal dialysis (PD) patients.

METHODS

This study obtained fasting blood samples from 76 PD patients. A validated tonometry system was used to measure cfPWV. Patients with cfPWV values >10 m/s were classified into the high arterial stiffness group, whereas patients with values ≤10 m/s were classified into the low arterial stiffness group, according to the ESH-ESC 2013 guidelines. Serum A-FABP levels were measured using a commercial enzyme-linked immunosorbent assay kit.

RESULTS

Twenty-five (32.9%) of the 76 PD patients were classified in the high arterial stiffness group. Compared with the patients in the low arterial stiffness group, the high arterial stiffness group was older ( = 0.002) and had a longer PD vintage ( = 0.011), higher diastolic blood pressure (DBP, = 0.036), higher fasting glucose levels ( = 0.012), higher serum C reactive protein levels ( = 0.001), and higher serum A-FABP levels ( < 0.001). A multivariate logistic regression analysis of the factors significantly associated with central arterial stiffness revealed that A-FABP (odds ratio (OR): 1.165, 95% confidence interval (CI): 1.056-1.284, = 0.002), age (OR: 1.423, 95% CI: 1.153-1.757, = 0.001), PD vintage (OR: 1.049, 95% CI: 1.015-1.085, = 0.005), and DBP (OR: 1.152, 95% CI: 1.033-1.285, = 0.011) were independent predictors of central arterial stiffness in PD patients. Furthermore, serum A-FABP levels ( = 0.476, adjusted change: 0.197, < 0.001) were significantly positively correlated with cfPWV according to the multivariable forward stepwise linear regression analysis.

CONCLUSIONS

A-FABP levels are an independent marker of central arterial stiffness in PD patients.

摘要

背景

脂肪细胞脂肪酸结合蛋白（A-FABP）在脂肪分解、胰岛素抵抗和动脉粥样硬化中起重要作用。本研究旨在评估腹膜透析（PD）患者血清A-FABP水平与颈股脉搏波速度（cfPWV）之间的关系。

方法

本研究采集了76例PD患者的空腹血样。使用经过验证的眼压测量系统测量cfPWV。根据欧洲高血压学会（ESH）和欧洲心脏病学会（ESC）2013年指南，cfPWV值>10 m/s的患者被分为高动脉僵硬度组，而cfPWV值≤10 m/s的患者被分为低动脉僵硬度组。使用商用酶联免疫吸附测定试剂盒测量血清A-FABP水平。

结果

76例PD患者中有25例（32.9%）被归类为高动脉僵硬度组。与低动脉僵硬度组患者相比，高动脉僵硬度组患者年龄更大（P = 0.002），腹膜透析病程更长（P = 0.011），舒张压（DBP）更高（P = 0.036），空腹血糖水平更高（P = 0.012），血清C反应蛋白水平更高（P = 0.001），血清A-FABP水平更高（P < 0.001）。对与中心动脉僵硬度显著相关的因素进行多变量逻辑回归分析显示，A-FABP（比值比（OR）：1.165，95%置信区间（CI）：1.056 - 1.284，P = 0.002）、年龄（OR：1.423，95%CI：1.153 - 1.757，P = 0.001）、腹膜透析病程（OR：1.049，95%CI：1.015 - 1.085，P = 0.005）和DBP（OR：1.152，95%CI：1.033 - 1.285，P = 0.011）是PD患者中心动脉僵硬度的独立预测因素。此外，根据多变量向前逐步线性回归分析，血清A-FABP水平（P = 0.476，调整R²变化：0.197，P < 0.001）与cfPWV显著正相关。