一氧化碳中毒。

Carbon Monoxide Poisoning.

机构信息

Department of Emergency Medicine, University of California - Davis, School of Medicine, 4150 V Street, PSSB Suite 2100, Sacramento, CA 95817, USA; Department of Internal Medicine, Mather VA Medical Center, 10535 Hospital Way, Mather, CA 95655, USA; Department of Internal Medicine, University of California - Davis, School of Medicine, 4150 V Street, PSSB Suite 3100, Sacramento, CA 95817, USA.

出版信息

Crit Care Clin. 2021 Jul;37(3):657-672. doi: 10.1016/j.ccc.2021.03.010.

DOI:10.1016/j.ccc.2021.03.010

PMID:34053712

Abstract

Carbon monoxide is a colorless, odorless, highly toxic gas primarily produced through the incomplete combustion of organic material. Carbon monoxide binds to hemoglobin and other heme molecules, causing tissue hypoxia and oxidative stress. Symptoms of carbon monoxide poisoning can vary from a mild headache to critical illness, which can make diagnosis difficult. When there is concern for possible carbon monoxide poisoning, the diagnosis can be made via blood co-oximetry. The primary treatment for patients with carbon monoxide poisoning is supplemental oxygen, usually delivered via a nonrebreather mask. Hyperbaric oxygen can also be used, but the exact indications are controversial.

摘要

一氧化碳是一种无色、无味、高毒性气体，主要由有机物质不完全燃烧产生。一氧化碳与血红蛋白和其他血红素分子结合，导致组织缺氧和氧化应激。一氧化碳中毒的症状从轻微头痛到严重疾病不等，这使得诊断变得困难。当怀疑可能存在一氧化碳中毒时，可以通过血一氧化碳-氧合测定进行诊断。一氧化碳中毒患者的主要治疗方法是补充氧气，通常通过无重复呼吸面罩提供。高压氧也可以使用，但确切的适应证存在争议。