Department of Pharmacognosy and Natural Products, Faculty of Pharmacy, Menoufia University, Gamal Abd El Nasr St., Shibin Elkom, Menoufia, 32511, Egypt.
Clinical Pharmacy Department, Shibin Elkom Teaching Hospitals, Gamal Abd El Nasr St., Shibin Elkom, Menoufia, 32511, Egypt.
Sci Rep. 2022 Apr 21;12(1):6578. doi: 10.1038/s41598-022-10494-4.
Aging has become a concern for many people, especially women. Given that high-quality anti-aging products are of high cost; it has imperative to search for other economical sources. Essential oils are frequently used in cosmetics products due to a wide range of biological activities as well as their pleasant odor. The current study aimed to investigate the biochemical effect of the cosmetic potential of selected Apiaceous essential oils, traditionally used for skincare, by evaluating their anti-wrinkle activity. It is worth noting that, coriander essential oil showed the highest collagenase, elastase, tyrosinase, and hyaluronidase inhibitory activities compared to other Apiaceous oils (fennel, anise, and cumin). GC-MS proved that coriander essential oil showed a very high level of oxygenated monoterpenes, with linalool (81.29%) as the most abundant constituent. Intriguingly, coriander oil cream and Coriander Essential Oil-loaded Lipid Nanoparticles (CEOLNs) formulations attenuated in vivo UV-induced skin photoaging that was manifested by significantly decreased MDA, COX-2, PGE-2, MMP-1, JNK, and AP-1 levels. Moreover, these pharmaceutical dosage forms significantly increased skin collagen content compared to UV-injured group. Also, coriander essential oil significantly increased TGFβ, TGFβII, and SMAD3 protein expression levels compared to UV-injured group. In conclusion, the pharmaceutical dosage forms of coriander oil possess anti-wrinkle activities that could have an auspicious role in amending extrinsic aging.
衰老是许多人关注的问题，尤其是女性。鉴于高质量的抗衰老产品成本高昂；因此有必要寻找其他经济实惠的来源。由于具有广泛的生物活性以及宜人的气味，精油经常被用于化妆品产品中。本研究旨在通过评估其抗皱活性，研究传统上用于皮肤护理的某些伞形科精油的化妆品潜力的生化作用。值得注意的是，与其他伞形科精油（茴香、八角和孜然）相比，芫荽精油显示出最高的胶原酶、弹性蛋白酶、酪氨酸酶和透明质酸酶抑制活性。GC-MS 证明芫荽精油显示出非常高水平的含氧单萜，其中芳樟醇（81.29%）为最丰富的成分。有趣的是，芫荽油霜和芫荽精油负载脂质纳米粒（CEOLNs）配方减轻了体内 UV 诱导的皮肤光老化，这表现为 MDA、COX-2、PGE-2、MMP-1、JNK 和 AP-1 水平显著降低。此外，与 UV 损伤组相比，这些药物剂型显著增加了皮肤胶原蛋白含量。此外，芫荽精油与 UV 损伤组相比，显著增加了 TGFβ、TGFβII 和 SMAD3 蛋白表达水平。总之，芫荽油的药物剂型具有抗皱活性，可能在纠正外在衰老方面发挥有益作用。
