Program on Reproductive Health and the Environment, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco School of Medicine, San Francisco, CA, USA.
Environmental Chemistry Laboratory, Department of Toxic Substances Control, California Environmental Protection Agency, Berkeley, CA, USA.
J Expo Sci Environ Epidemiol. 2023 Jul;33(4):548-557. doi: 10.1038/s41370-022-00426-9. Epub 2022 Apr 21.
Differential risks for adverse pregnancy outcomes may be influenced by prenatal chemical exposures, but current exposure methods may not fully capture data to identify harms and differences.
We collected maternal and cord sera from pregnant people in Fresno and San Francisco, and screened for over 2420 chemicals using LC-QTOF/MS. We matched San Francisco participants to Fresno participants (N = 150) and compared detection frequencies. Twenty-six Fresno participants wore silicone wristbands evaluated for over 1500 chemicals using quantitative chemical analysis. We assessed whether living in tracts with higher levels of pollution according to CalEnviroScreen correlated with higher numbers of chemicals detected in sera.
We detected 2167 suspect chemical features across maternal and cord sera. The number of suspect chemical features was not different by city, but a higher number of suspect chemicals in cosmetics or fragrances was detected in the Fresno versus San Francisco participants' sera. We also found high levels of chemicals used in fragrances measured in the silicone wristbands. Fresno participants living in tracts with higher pesticide scores had higher numbers of suspect pesticides in their sera.
Multiple exposure-assessment approaches can identify exposure to many chemicals during pregnancy that have not been well-studied for health effects.
妊娠结局不良的风险可能因产前化学暴露而异，但目前的暴露方法可能无法充分收集数据以识别危害和差异。
我们从弗雷斯诺和旧金山的孕妇中采集了母体和脐带血清，并使用 LC-QTOF/MS 对超过 2420 种化学物质进行了筛查。我们将旧金山的参与者与弗雷斯诺的参与者进行了匹配（N=150），并比较了检测频率。26 名弗雷斯诺参与者佩戴了硅胶手环，使用定量化学分析评估了超过 1500 种化学物质。我们评估了根据 CalEnviroScreen 居住在污染水平较高的地区是否与血清中检测到的化学物质数量增加有关。
我们在母体和脐带血清中检测到了 2167 种可疑化学特征。血清中可疑化学特征的数量不因城市而异，但弗雷斯诺参与者血清中化妆品或香水类的可疑化学物质数量高于旧金山参与者。我们还发现，硅胶手环中测量到的香水用化学物质含量较高。居住在农药分数较高的地区的弗雷斯诺参与者，其血清中可疑农药的数量更多。
多种暴露评估方法可以识别出怀孕期间接触到许多尚未充分研究其健康影响的化学物质。
