Nicholas School of the Environment , Duke University , Durham , North Carolina 27708 , United States.
Environ Sci Technol. 2018 Oct 16;52(20):11875-11885. doi: 10.1021/acs.est.8b03755. Epub 2018 Oct 2.
Biomarkers remain the gold standard for assessing chemical exposure. However, silicone wristbands may provide some added benefits for characterizing personal exposures compared to single biomarker measurements, such as decreased costs, noninvasive sampling, and increased ease of analysis. Previously, we validated their use in characterizing exposure to organophosphate flame retardants (PFRs). However, it is unclear whether these results would extend to chemicals like polybrominated diphenyl ethers (PBDEs), which biomagnify and have longer half-lives than PFRs in the body. This study sought to determine if accumulation of PBDEs on wristbands was correlated to serum biomarkers. Adult participants ( n = 30) provided serum samples and wore wristbands for 7 days. PBDEs and 6 novel brominated flame retardants (BFRs) were measured on wristbands, and serum samples were analyzed for PBDE biomarkers. Like most PBDE congeners, 5 of 6 novel BFRs were frequently detected on wristbands (≥90% of bands). In particular, decabromodiphenyl ethane (DBDPE) was detected in all wristbands in this study and was significantly correlated with BDE-209, suggesting a similar source and exposure pathway. Wristband levels of BDE-47, -99, -100, and -153 were significantly and positively associated with respective serum biomarkers ( r = 0.39-0.57, p < 0.05). This study demonstrates that silicone wristbands can accurately detect personal PBDE exposures.
生物标志物仍然是评估化学暴露的金标准。然而，与单个生物标志物测量相比，硅橡胶手环可能为个人暴露特征提供一些额外的好处，例如降低成本、非侵入性采样和增加分析的便利性。此前，我们已经验证了它们在表征有机磷酸酯阻燃剂（PFRs）暴露中的应用。然而，目前尚不清楚这些结果是否会扩展到类似多溴二苯醚（PBDEs）等化学物质，这些化学物质在体内比 PFRs 更具生物放大性和更长的半衰期。本研究旨在确定手环上 PBDEs 的积累是否与血清生物标志物相关。30 名成年参与者提供了血清样本，并佩戴手环 7 天。在手环上测量了 PBDEs 和 6 种新型溴化阻燃剂（BFRs），并分析了血清样本中的 PBDE 生物标志物。与大多数 PBDE 同系物一样，6 种新型 BFR 中有 5 种（≥90%的手环）经常被检测到。特别是在本研究中，所有手环都检测到了十溴二苯乙烷（DBDPE），并且与 BDE-209 显著相关，表明它们具有相似的来源和暴露途径。BDE-47、-99、-100 和 -153 的手环水平与各自的血清生物标志物呈显著正相关（r = 0.39-0.57，p < 0.05）。本研究表明，硅橡胶手环可以准确地检测个人 PBDE 暴露。
