Qiu Longhai, Zhu Zhanbei, Peng Feng, Zhang Chi, Xie Juning, Zhou Ruixiang, Zhang Yu, Li Mei
The Second School of Clinical Medicine, Southern Medical University, Guangzhou 510515, China.
Medical Research Center, Department of Orthopedics, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China.
ACS Omega. 2022 Apr 3;7(14):12030-12038. doi: 10.1021/acsomega.2c00229. eCollection 2022 Apr 12.
Aseptic loosening is the main factor that leads to the failure of orthopedic implants. Enhancing the early osteointegration of a bone implant can lower the risk of aseptic loosening. Here, a Li-doped surface was constructed on a Ti surface via plasma electrolytic oxidation (PEO) to improve osteointegration. The prepared Li-doped PEO coating showed a porous morphology and the sustained release of Li ions. results of rat bone marrow mesenchymal stem cell (rBMSC) culture studies suggested that the Li-doped Ti surface significantly favored cell adhesion. Moreover, it was found that the Li-doped surface enhanced alkaline phosphatase activity and extracellular matrix mineralization of rBMSCs. In addition, the surface improved the expression of osteogenesis-related genes. Furthermore, a bone implantation model indicated that the Li-doped Ti surface showed improved osteointegration. The incorporation of Li into a Ti surface is a promising method for orthopedic applications.
无菌性松动是导致骨科植入物失败的主要因素。增强骨植入物的早期骨整合可以降低无菌性松动的风险。在此，通过等离子体电解氧化（PEO）在钛表面构建了锂掺杂表面，以改善骨整合。制备的锂掺杂PEO涂层呈现出多孔形态并能持续释放锂离子。大鼠骨髓间充质干细胞（rBMSC）培养研究结果表明，锂掺杂钛表面显著有利于细胞黏附。此外，发现锂掺杂表面增强了rBMSC的碱性磷酸酶活性和细胞外基质矿化。另外，该表面改善了成骨相关基因的表达。此外，骨植入模型表明锂掺杂钛表面的骨整合得到了改善。将锂掺入钛表面是一种有前景的骨科应用方法。
