Xue Nannan, Ding Xiaofeng, Huang Rizhong, Jiang Ruihan, Huang Heyan, Pan Xin, Min Wen, Chen Jun, Duan Jin-Ao, Liu Pei, Wang Yiwei
Jiangsu Provincial Engineering Research Center of Traditional Chinese Medicine External Medication Development and Application, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Jiangsu Key Laboratory for High Technology Research of TCM Formulae, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Pharmaceuticals (Basel). 2022 Jul 17;15(7):879. doi: 10.3390/ph15070879.
Bones play an important role in maintaining exercise and protecting organs. Bone defect, as a common orthopedic disease in clinics, can cause tremendous damage with long treatment cycles. Therefore, the treatment of bone defect remains as one of the main challenges in clinical practice. Today, with increased incidence of bone disease in the aging population, demand for bone repair material is high. At present, the method of clinical treatment for bone defects including non-invasive therapy and invasive therapy. Surgical treatment is the most effective way to treat bone defects, such as using bone grafts, Masquelet technique, Ilizarov technique etc. In recent years, the rapid development of tissue engineering technology provides a new treatment strategy for bone repair. This review paper introduces the current situation and challenges of clinical treatment of bone defect repair in detail. The advantages and disadvantages of bone tissue engineering scaffolds are comprehensively discussed from the aspect of material, preparation technology, and function of bone tissue engineering scaffolds. This paper also summarizes the 3D printing technology based on computer technology, aiming at designing personalized artificial scaffolds that can accurately fit bone defects.
骨骼在维持运动和保护器官方面发挥着重要作用。骨缺损作为临床上常见的骨科疾病，会造成巨大损害且治疗周期长。因此，骨缺损的治疗仍然是临床实践中的主要挑战之一。如今，随着老龄化人口中骨病发病率的上升，对骨修复材料的需求很高。目前，骨缺损的临床治疗方法包括非侵入性治疗和侵入性治疗。手术治疗是治疗骨缺损最有效的方法，如使用骨移植、Masquelet技术、Ilizarov技术等。近年来，组织工程技术的快速发展为骨修复提供了一种新的治疗策略。本文详细介绍了骨缺损修复临床治疗的现状和挑战。从骨组织工程支架的材料、制备技术和功能方面全面讨论了其优缺点。本文还总结了基于计算机技术的3D打印技术，旨在设计能够精确适配骨缺损的个性化人工支架。
