螯合脂肪的好处：受铁调控的脂滴生物发生先于并维持线粒体自噬。
The goodies of chelated fat: iron-regulated lipid droplet biogenesis precedes and preserves mitophagy.
机构信息
Institut de Biologia Molecular de Barcelona (IBMB-CSIC), Barcelona, Spain.
Department of Medicine, Endocrinology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
出版信息
EMBO J. 2022 May 16;41(10):e111238. doi: 10.15252/embj.2022111238. Epub 2022 Apr 22.
Abstract
The role of iron-regulated mitophagy in lipid metabolism is unclear. Recent work by Long, Sanchez-Martinez et al (2022) shows that iron chelation induces a primary change in lipid metabolism that promotes fat accumulation and precedes mitophagy.
摘要
铁调节的线粒体自噬在脂质代谢中的作用尚不清楚。龙、桑切斯-马丁内斯等人（2022 年）的最新研究表明，铁螯合作用会引起脂质代谢的主要变化，促进脂肪积累，并先于线粒体自噬。
相似文献
1
The goodies of chelated fat: iron-regulated lipid droplet biogenesis precedes and preserves mitophagy.螯合脂肪的好处：受铁调控的脂滴生物发生先于并维持线粒体自噬。
EMBO J. 2022 May 16;41(10):e111238. doi: 10.15252/embj.2022111238. Epub 2022 Apr 22.
2
Lipid droplets promote efficient mitophagy.脂滴促进有效的线粒体自噬。
Autophagy. 2023 Feb;19(2):724-725. doi: 10.1080/15548627.2022.2089956. Epub 2022 Aug 8.
3
Cold exposure alters lipid metabolism of skeletal muscle through HIF-1α-induced mitophagy.冷暴露通过 HIF-1α 诱导的线粒体自噬改变骨骼肌的脂质代谢。
BMC Biol. 2023 Feb 8;21(1):27. doi: 10.1186/s12915-023-01514-4.
4
The why, when and how of lipid droplet diversity.脂滴多样性的原因、时间及方式。
J Cell Sci. 2017 Jan 15;130(2):315-324. doi: 10.1242/jcs.192021. Epub 2017 Jan 3.
5
Lipid Droplet Metabolism during Dengue Virus Infection.登革病毒感染期间的脂滴代谢。
Trends Microbiol. 2018 Aug;26(8):640-642. doi: 10.1016/j.tim.2018.05.010. Epub 2018 Jun 13.
6
Defective mitochondrial ISCs biogenesis switches on IRP1 to fine tune selective mitophagy.缺陷的线粒体 ISCs 生物发生激活 IRP1 以精细调节选择性线粒体自噬。
Redox Biol. 2020 Sep;36:101661. doi: 10.1016/j.redox.2020.101661. Epub 2020 Jul 27.
7
Making Droplet-Embedded Vesicles to Model Cellular Lipid Droplets.制备液滴嵌入囊泡以模拟细胞脂滴。
STAR Protoc. 2020 Sep 25;1(3):100116. doi: 10.1016/j.xpro.2020.100116. eCollection 2020 Dec 18.
8
The origin and development of fat droplet and its role in health and illness.脂肪滴的起源与发展及其在健康与疾病中的作用。
Cas Lek Cesk. 2018 Fall;157(5):254-262.
9
Iron chelation promotes mitophagy through SENP3-mediated deSUMOylation of FIS1.铁螯合作用通过 SENP3 介导的 FIS1 的去 SUMOylation 促进线粒体自噬。
Autophagy. 2022 Jul;18(7):1743-1745. doi: 10.1080/15548627.2022.2046898. Epub 2022 Mar 11.
10
Acute loss of iron-sulfur clusters results in metabolic reprogramming and generation of lipid droplets in mammalian cells.急性铁硫簇缺失导致哺乳动物细胞代谢重编程和脂滴生成。
J Biol Chem. 2018 May 25;293(21):8297-8311. doi: 10.1074/jbc.RA118.001885. Epub 2018 Mar 9.
引用本文的文献
1
Gene fusion and functional diversification of genes facilitate thermophilic fungal adaptation to temperature change.基因融合与基因功能多样化促进嗜热真菌适应温度变化。
Mycology. 2024 Apr 2;15(3):485-505. doi: 10.1080/21501203.2024.2324993. eCollection 2024.
2
Mitophagy in the aging nervous system.衰老神经系统中的线粒体自噬
Front Cell Dev Biol. 2022 Oct 11;10:978142. doi: 10.3389/fcell.2022.978142. eCollection 2022.
本文引用的文献
1
DGAT1 activity synchronises with mitophagy to protect cells from metabolic rewiring by iron depletion.DGAT1 活性与线粒体自噬同步，以保护细胞免受铁耗竭引起的代谢重排。
EMBO J. 2022 May 16;41(10):e109390. doi: 10.15252/embj.2021109390. Epub 2022 Apr 12.
2
The SUMO protease SENP3 regulates mitochondrial autophagy mediated by Fis1.SUMO 蛋白酶 SENP3 通过 Fis1 调节线粒体自噬。
EMBO Rep. 2022 Feb 3;23(2):e48754. doi: 10.15252/embr.201948754. Epub 2022 Jan 7.
3
Iron loss triggers mitophagy through induction of mitochondrial ferritin.铁丢失通过诱导线粒体铁蛋白触发线粒体自噬。
EMBO Rep. 2020 Nov 5;21(11):e50202. doi: 10.15252/embr.202050202. Epub 2020 Sep 25.
4
MIGA2 Links Mitochondria, the ER, and Lipid Droplets and Promotes De Novo Lipogenesis in Adipocytes.MIGA2 将线粒体、内质网和脂滴联系起来，并促进脂肪细胞中的从头脂肪生成。
Mol Cell. 2019 Dec 5;76(5):811-825.e14. doi: 10.1016/j.molcel.2019.09.011. Epub 2019 Oct 15.
5
Mitochondria Bound to Lipid Droplets: Where Mitochondrial Dynamics Regulate Lipid Storage and Utilization.线粒体与脂滴结合：线粒体动态调节脂质储存和利用的地方。
Cell Metab. 2019 Apr 2;29(4):827-835. doi: 10.1016/j.cmet.2019.02.011. Epub 2019 Mar 21.
6
Reduction in mitochondrial iron alleviates cardiac damage during injury.线粒体铁含量的降低可减轻损伤期间的心脏损伤。
EMBO Mol Med. 2016 Mar 1;8(3):247-67. doi: 10.15252/emmm.201505748.
7
Hepatic triacylglycerol synthesis and secretion: DGAT2 as the link between glycaemia and triglyceridaemia.肝脏三酰甘油的合成与分泌：DGAT2 将血糖与血三酰甘油联系起来。
Biochem J. 2013 Apr 1;451(1):1-12. doi: 10.1042/BJ20121689.
8
The endoplasmic reticulum enzyme DGAT2 is found in mitochondria-associated membranes and has a mitochondrial targeting signal that promotes its association with mitochondria.内质网酶二酰甘油酰基转移酶2（DGAT2）存在于线粒体相关膜中，并且具有促进其与线粒体结合的线粒体靶向信号。
J Biol Chem. 2009 Feb 20;284(8):5352-61. doi: 10.1074/jbc.M805768200. Epub 2008 Dec 1.
9
10
Comparative study of iron mobilization from haemosiderin, ferritin and iron(III) precipitates by chelators.螯合剂对含铁血黄素、铁蛋白和铁（III）沉淀物中铁动员的比较研究。
Biochem J. 1987 Jan 1;241(1):87-92. doi: 10.1042/bj2410087.
Zotero 插件