登革病毒感染期间的脂滴代谢。
Lipid Droplet Metabolism during Dengue Virus Infection.
机构信息
Department of Microbiology, The University of Chicago, Chicago, IL 60637, USA.
出版信息
Trends Microbiol. 2018 Aug;26(8):640-642. doi: 10.1016/j.tim.2018.05.010. Epub 2018 Jun 13.
PMID:29909044
Abstract
Dengue virus (DENV) induces a proviral selective autophagy targeting lipid droplets, termed lipophagy, that stimulates lipid metabolism. Zhang et al. gained mechanistic insight into this process, demonstrating that DENV NS4A/B binds unmodified AUP1 and promotes its translocation from lipid droplets to autophagosomes to drive the induction of lipophagy.
摘要
登革热病毒（DENV）诱导靶向脂滴的前病毒选择性自噬，称为脂噬，从而刺激脂质代谢。Zhang 等人深入了解了这一过程，表明 DENV NS4A/B 结合未修饰的 AUP1 并促进其从脂滴向自噬体易位，从而驱动脂噬的诱导。
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