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[特瑞替林对抗真菌抗生素活性的影响]

[Effect of terrilytin on antifungal antibiotic activity].

作者信息

Bogdanov V V

出版信息

Antibiotiki. 1978 Jul;23(7):622-5.

PMID:354511
Abstract

The antifungal activity of terrilitine, an enzymatic preparation of microbial origin and its effect on the activity of antifungal polyenic antibiotics and griseofulvine were studied in vitro. It was found with the method of serial dilutions in Sabourand's liquid medium that terrilitine was active against C. albicans and certain dermatophytes. In combination with amphotericin B, amphoglucamine, mycoheptine, levorin, nystatin or griseofulvin it increased the activity of these antibiotics 2-16 times.

摘要

研究了微生物来源的酶制剂特立菌素的抗真菌活性及其对抗真菌多烯类抗生素和灰黄霉素活性的影响。在沙氏液体培养基中采用系列稀释法发现,特立菌素对白色念珠菌和某些皮肤癣菌具有活性。与两性霉素B、两性葡胺、霉酚酸、利沃菌素、制霉菌素或灰黄霉素联合使用时,它可使这些抗生素的活性提高2至16倍。

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