Department of Periodontology, Faculty of Dentistry, Hatay Mustafa Kemal University, Hatay, Turkey.
Department of Clinical Microbiology, Faculty of Medicine, Hatay Mustafa Kemal University, Hatay, Turkey.
Clin Oral Investig. 2022 Aug;26(8):5351-5358. doi: 10.1007/s00784-022-04502-0. Epub 2022 Apr 22.
The aim of this study was to evaluate the levels of salivary and serum interleukin (IL)-1β, visfatin, and omentin-1 in the relationship between periodontal disease and overweight/obesity as well as to reveal the possible role of periodontal inflamed surface area (PISA) in this association.
Ninety-six individuals (69 females, 27 males) were divided into 4 groups as systemically healthy (H) and non-periodontitis (HnP, n = 23), systemically healthy and periodontitis (HP, n = 24), overweight/obese (O) and non-periodontitis (OnP, n = 25), and overweight/obese and periodontitis (OP, n = 24). Periodontal parameters were measured, and PISA was calculated. IL-1β, visfatin, and omentin-1 levels in saliva and serum samples were analysed.
Periodontal parameters deteriorated, salivary and serum IL-1β and visfatin levels were increased, and omentin-1 levels were decreased in OnP and OP groups, compared to HnP and HP groups. Salivary and serum IL-1β and visfatin levels were increased and omentin-1 levels were decreased in periodontitis groups, compared to HnP and OnP groups. PISA was negatively correlated with salivary omentin-1 and positively correlated with salivary and serum visfatin in H and O groups, whereas a positive relationship was found between PISA and salivary and serum IL-1β in H group.
PISA may be negatively associated with salivary omentin-1, while positively correlated with salivary and serum visfatin in overweight/obese patients.
Co-evaluation of PISA and adipokines seems to be an innovative approach to evaluate the association between periodontitis and overweight/obesity.
本研究旨在评估唾液和血清白细胞介素（IL）-1β、内脏脂肪素和网膜素-1水平在牙周病与超重/肥胖之间的关系，并揭示牙周炎炎症表面面积（PISA）在这种关联中的可能作用。
96 名个体（69 名女性，27 名男性）分为 4 组：全身健康且无牙周炎（HnP，n=23）、全身健康且牙周炎（HP，n=24）、超重/肥胖且无牙周炎（OnP，n=25）和超重/肥胖且牙周炎（OP，n=24）。测量牙周参数并计算 PISA。分析唾液和血清样本中 IL-1β、内脏脂肪素和网膜素-1的水平。
与 HnP 和 HP 组相比，OnP 和 OP 组的牙周参数恶化，唾液和血清 IL-1β 和内脏脂肪素水平升高，网膜素-1水平降低。与 HnP 和 OnP 组相比，牙周炎组的唾液和血清 IL-1β 和内脏脂肪素水平升高，网膜素-1水平降低。在 H 和 O 组中，PISA 与唾液网膜素-1呈负相关，与唾液和血清内脏脂肪素呈正相关，而在 H 组中，PISA 与唾液和血清 IL-1β 呈正相关。
在超重/肥胖患者中，PISA 可能与唾液网膜素-1呈负相关，与唾液和血清内脏脂肪素呈正相关。
同时评估 PISA 和脂肪因子似乎是评估牙周炎与超重/肥胖之间关系的一种创新方法。
