Hao Guihua, Zhao Xiaomei, Fu Weiwei, Wu Yiwen, Dai Jingjing, Qian Yifeng, Xie Tian, Hou Lili, Shi Wentao
Department of Nursing, Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
Shanghai Jiao Tong University School of Nursing, Shanghai, China.
Front Nutr. 2024 Nov 11;11:1423424. doi: 10.3389/fnut.2024.1423424. eCollection 2024.
The Oxidative Balance Score (OBS), which reflects overall oxidation through diet and lifestyle, has been linked to sleep, but few studies have clarified this relationship. We investigated the association between OBS and sleep duration, and whether oxidative stress (OS) and inflammation mediate the underlying mechanisms.
Data were obtained from the National Health and Nutrition Examination Survey spanning the years 2007 to 2018. Multivariable logistic regression analyses were used to evaluate the association between OBS and the risk of sleep duration. Mediation analyses were conducted to investigate the role of OS and inflammatory markers.
A significant negative association was found between OBS and sleep duration ( < 0.01). Meanwhile, compared to participants in OBS tertile 1, the ORs (95% CIs) of incident short sleep duration were 0.78 (0.72-0.86) and 0.72 (0.67-0.79) (both < 0.01) for OBS tertile 2 and 3, respectively. And the ORs (95% CIs) of incident long sleep duration were 0.83 (0.73, 0.95) and 0.66 (0.57, 0.75) (both < 0.01) for OBS tertiles 2 and 3 after adjustment for multivariate variables. A linear relationship between OBS and short/long sleep duration ( for non-linearity = 0.69/0.94, both < 0.01) were revealed. Mediation analysis showed absolute neutrophil count, serum total bilirubin mediated the association between OBS and short/long sleep duration with 5.72, 13.41% proportion of mediation, respectively (both < 0.001).
OBS is negatively associated with sleep duration. OS and inflammatory biomarkers mediate the relationship.
氧化平衡评分（OBS）通过饮食和生活方式反映整体氧化状态，其与睡眠有关联，但很少有研究阐明这种关系。我们调查了OBS与睡眠时间之间的关联，以及氧化应激（OS）和炎症是否介导了潜在机制。
数据来自2007年至2018年的美国国家健康与营养检查调查。采用多变量逻辑回归分析评估OBS与睡眠时间风险之间的关联。进行中介分析以研究OS和炎症标志物的作用。
发现OBS与睡眠时间之间存在显著负相关（<0.01）。同时，与OBS三分位数1的参与者相比，OBS三分位数2和3的 incident short sleep duration的优势比（95%置信区间）分别为0.78（0.72 - 0.86）和0.72（0.67 - 0.79）（均<0.01）。在对多变量进行调整后，OBS三分位数2和3的incident long sleep duration的优势比（95%置信区间）分别为0.83（0.73，0.95）和0.66（0.57，0.75）（均<0.01）。揭示了OBS与短/长睡眠时间之间的线性关系（非线性检验P值=0.69/0.94，均<0.01）。中介分析表明，绝对中性粒细胞计数、血清总胆红素分别介导了OBS与短/长睡眠时间之间的关联，中介比例分别为5.72%、13.41%（均<0.001）。
OBS与睡眠时间呈负相关。OS和炎症生物标志物介导了这种关系。
