• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Overcoming the challenge of long-term storage of mRNA-lipid nanoparticle vaccines.克服mRNA-脂质纳米颗粒疫苗长期储存的挑战。
Mol Ther. 2022 May 4;30(5):1792-1793. doi: 10.1016/j.ymthe.2022.04.004. Epub 2022 Apr 22.
2
Lyophilization provides long-term stability for a lipid nanoparticle-formulated, nucleoside-modified mRNA vaccine.冷冻干燥为脂质纳米颗粒配方、核苷修饰的 mRNA 疫苗提供了长期稳定性。
Mol Ther. 2022 May 4;30(5):1941-1951. doi: 10.1016/j.ymthe.2022.02.001. Epub 2022 Feb 4.
3
Advances in mRNA vaccines.mRNA 疫苗的进展。
Int Rev Cell Mol Biol. 2022;372:295-316. doi: 10.1016/bs.ircmb.2022.04.011. Epub 2022 Jun 21.
4
Novel Lipid Nanoparticles Stable and Efficient for mRNA Transfection to Antigen-Presenting Cells.新型脂质纳米颗粒稳定且高效地转染抗原呈递细胞的 mRNA。
Int J Mol Sci. 2024 Jan 23;25(3):1388. doi: 10.3390/ijms25031388.
5
Protocol for the development of mRNA lipid nanoparticle vaccines and analysis of immunization efficiency in mice.mRNA 脂质纳米粒疫苗的研制方案及小鼠免疫效力分析。
STAR Protoc. 2024 Jun 21;5(2):103087. doi: 10.1016/j.xpro.2024.103087. Epub 2024 May 23.
6
A Basic Method for Formulating mRNA-Lipid Nanoparticle Vaccines in the Lab.一种在实验室中制备mRNA脂质纳米颗粒疫苗的基本方法。
Methods Mol Biol. 2024;2786:237-254. doi: 10.1007/978-1-0716-3770-8_11.
7
Research Advances on the Stability of mRNA Vaccines.mRNA 疫苗稳定性研究进展。
Viruses. 2023 Mar 2;15(3):668. doi: 10.3390/v15030668.
8
Elucidation of lipid nanoparticle surface structure in mRNA vaccines.阐明 mRNA 疫苗中脂质纳米颗粒的表面结构。
Sci Rep. 2023 Oct 5;13(1):16744. doi: 10.1038/s41598-023-43898-x.
9
The role of nanoparticle format and route of administration on self-amplifying mRNA vaccine potency.纳米颗粒形式和给药途径对自扩增 mRNA 疫苗效力的影响。
J Control Release. 2022 Feb;342:388-399. doi: 10.1016/j.jconrel.2021.12.008. Epub 2021 Dec 10.
10
mRNA Synthesis and Encapsulation in Ionizable Lipid Nanoparticles.mRNA 的离子脂质纳米颗粒合成与包封。
Curr Protoc. 2023 Sep;3(9):e898. doi: 10.1002/cpz1.898.

引用本文的文献

1
Freeze-Drying of mRNA-LNPs Vaccines: A Review.mRNA-脂质纳米颗粒疫苗的冷冻干燥：综述
Vaccines (Basel). 2025 Aug 12;13(8):853. doi: 10.3390/vaccines13080853.
2
Lipid Nanoparticles Formulated with a Novel Cholesterol-Tailed Ionizable Lipid Markedly Increase mRNA Delivery Both in vitro and in vivo.用一种新型胆固醇尾可电离脂质配制的脂质纳米颗粒在体外和体内均显著提高mRNA递送效率。
Int J Nanomedicine. 2025 Jul 28;20:9389-9405. doi: 10.2147/IJN.S527822. eCollection 2025.
3
Current Progress and Future Perspectives of RNA-Based Cancer Vaccines: A 2025 Update.基于RNA的癌症疫苗的当前进展与未来展望：2025年更新
Cancers (Basel). 2025 Jun 4;17(11):1882. doi: 10.3390/cancers17111882.
4
Nanoparticle-formulated mRNA encoding engineered multivalent SIRPα-Fc fusion proteins shows robust anti-cancer activity in preclinical models.纳米颗粒配方的编码工程化多价信号调节蛋白α-免疫球蛋白Fc段融合蛋白的信使核糖核酸在临床前模型中显示出强大的抗癌活性。
Mol Ther Nucleic Acids. 2025 Apr 29;36(2):102550. doi: 10.1016/j.omtn.2025.102550. eCollection 2025 Jun 10.
5
Revolutionizing immunization: a comprehensive review of mRNA vaccine technology and applications.免疫接种的变革：mRNA疫苗技术与应用的全面综述
Virol J. 2025 Mar 12;22(1):71. doi: 10.1186/s12985-025-02645-6.
6
Mechanisms of extracellular vesicle uptake and implications for the design of cancer therapeutics.细胞外囊泡摄取机制及其对癌症治疗设计的影响。
J Extracell Biol. 2024 Oct 30;3(11):e70017. doi: 10.1002/jex2.70017. eCollection 2024 Nov.
7
Aptamer-Targeted Dendrimersomes Assembled from Azido-Modified Janus Dendrimers "Clicked" to DNA.由叠氮基修饰的 Janus 树枝状大分子“点击”到 DNA 上组装而成的适配体靶向树枝状脂质体。
Biomacromolecules. 2024 Mar 11;25(3):1541-1549. doi: 10.1021/acs.biomac.3c01108. Epub 2024 Feb 23.
8
Circular RNA vaccines with long-term lymph node-targeting delivery stability after lyophilization induce potent and persistent immune responses.经冷冻干燥后仍具有长期淋巴结靶向递药稳定性的环状 RNA 疫苗可诱导强烈且持久的免疫应答。
mBio. 2024 Jan 16;15(1):e0177523. doi: 10.1128/mbio.01775-23. Epub 2023 Dec 11.
9
Just Keep Rolling?-An Encompassing Review towards Accelerated Vaccine Product Life Cycles.持续推进？——关于加速疫苗产品生命周期的全面综述
Vaccines (Basel). 2023 Jul 27;11(8):1287. doi: 10.3390/vaccines11081287.
10
Interactome of Long Non-Coding RNAs: Transcriptomic Expression Patterns and Shaping Cancer Cell Phenotypes.长非编码 RNA 的相互作用组：转录组表达模式和塑造癌细胞表型。
Int J Mol Sci. 2023 Jun 8;24(12):9914. doi: 10.3390/ijms24129914.

本文引用的文献

1
Lyophilized mRNA-lipid nanoparticle vaccines with long-term stability and high antigenicity against SARS-CoV-2.具有长期稳定性和针对严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的高抗原性的冻干信使核糖核酸-脂质纳米颗粒疫苗。
Cell Discov. 2023 Jan 23;9(1):9. doi: 10.1038/s41421-022-00517-9.
2
Lyophilization provides long-term stability for a lipid nanoparticle-formulated, nucleoside-modified mRNA vaccine.冷冻干燥为脂质纳米颗粒配方、核苷修饰的 mRNA 疫苗提供了长期稳定性。
Mol Ther. 2022 May 4;30(5):1941-1951. doi: 10.1016/j.ymthe.2022.02.001. Epub 2022 Feb 4.
3
Ionizable lipid nanoparticles for in utero mRNA delivery.用于子宫内mRNA递送的可电离脂质纳米颗粒。
Sci Adv. 2021 Jan 13;7(3). doi: 10.1126/sciadv.aba1028. Print 2021 Jan.
4
Addressing the Cold Reality of mRNA Vaccine Stability.解决 mRNA 疫苗稳定性的冷酷现实。
J Pharm Sci. 2021 Mar;110(3):997-1001. doi: 10.1016/j.xphs.2020.12.006. Epub 2020 Dec 13.
5
Long-term storage of lipid-like nanoparticles for mRNA delivery.用于mRNA递送的类脂质纳米颗粒的长期储存。
Bioact Mater. 2020 Mar 18;5(2):358-363. doi: 10.1016/j.bioactmat.2020.03.001. eCollection 2020 Jun.
6
Protective Effect of Saccharides on Freeze-Dried Liposomes Encapsulating Drugs.糖类对包封药物的冻干脂质体的保护作用。
Front Bioeng Biotechnol. 2019 Dec 17;7:424. doi: 10.3389/fbioe.2019.00424. eCollection 2019.
7
Delivering the Messenger: Advances in Technologies for Therapeutic mRNA Delivery.传递信使：治疗性 mRNA 递送技术的进展。
Mol Ther. 2019 Apr 10;27(4):710-728. doi: 10.1016/j.ymthe.2019.02.012. Epub 2019 Feb 19.
8
Delivery technologies for cancer immunotherapy.癌症免疫疗法的递药技术。
Nat Rev Drug Discov. 2019 Mar;18(3):175-196. doi: 10.1038/s41573-018-0006-z.
9
Patisiran, an RNAi Therapeutic, for Hereditary Transthyretin Amyloidosis.用于遗传性转甲状腺素蛋白淀粉样变性的 RNAi 治疗药物 Patisiran
N Engl J Med. 2018 Jul 5;379(1):11-21. doi: 10.1056/NEJMoa1716153.
10
Achieving long-term stability of lipid nanoparticles: examining the effect of pH, temperature, and lyophilization.实现脂质纳米颗粒的长期稳定性：研究pH值、温度和冻干的影响。
Int J Nanomedicine. 2016 Dec 30;12:305-315. doi: 10.2147/IJN.S123062. eCollection 2017.

Overcoming the challenge of long-term storage of mRNA-lipid nanoparticle vaccines.

作者信息

Young Rachel E, Hofbauer Samuel I, Riley Rachel S

机构信息

Department of Biomedical Engineering, Rowan University, Glassboro, NJ 08028, USA.

Department of Biomedical Engineering, Rowan University, Glassboro, NJ 08028, USA.

出版信息

Mol Ther. 2022 May 4;30(5):1792-1793. doi: 10.1016/j.ymthe.2022.04.004. Epub 2022 Apr 22.

DOI:10.1016/j.ymthe.2022.04.004
PMID:35452599
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9023316/
Abstract
摘要