Ścibior Agnieszka
Laboratory of Oxidative Stress, Centre for Interdisciplinary Research, The John Paul II Catholic University of Lublin, 20-708 Lublin, Poland.
Antioxidants (Basel). 2022 Apr 17;11(4):790. doi: 10.3390/antiox11040790.
The present review was conducted to gather the available literature on some issues related to vanadium-quercetin (V-QUE) complexes. It was aimed at collecting data from in vitro and in vivo studies on the biological activity, behavior, antioxidant properties, and radical scavenging power of V-QUE complexes. The analysis of relevant findings allowed summarizing the evidence for the antidiabetic and anticarcinogenic potential of V-QUE complexes and suggested that they could serve as pharmacological agents for diabetes and cancer. These data together with other well-documented biological properties of V and QUE (common for both), which are briefly summarized in this review as well, may lay the groundwork for new therapeutic treatments and further research on a novel class of pharmaceutical molecules with better therapeutic performance. Simultaneously, the results compiled in this report point to the need for further studies on complexation of V with flavonoids to gain further insight into their behavior, identify species responsible for their physiological activity, and fully understand their mechanism of action.
本综述旨在收集有关钒-槲皮素（V-QUE）复合物相关问题的现有文献。其目的是从体外和体内研究中收集关于V-QUE复合物的生物活性、行为、抗氧化特性和自由基清除能力的数据。对相关研究结果的分析总结了V-QUE复合物具有抗糖尿病和抗癌潜力的证据，并表明它们可作为治疗糖尿病和癌症的药物。这些数据以及本文简要总结的V和QUE（两者共有的）其他充分记录的生物学特性，可能为新的治疗方法以及对具有更好治疗性能的新型药物分子的进一步研究奠定基础。同时，本报告汇总的结果表明，需要进一步研究V与黄酮类化合物的络合作用，以更深入了解它们的行为，确定负责其生理活性的物种，并充分理解其作用机制。
