de Sousa Neto Ivo Vieira, da Cunha Nascimento Dahan, Prestes Jonato, da Fonseca Eduardo Fernandes, Celes Rodrigo Souza, Rolnick Nicholas, de Sousa Barbalho Yuri Gustavo, Silva Alessandro de Oliveira, Stival Marina Morato, de Lima Luciano Ramos, Funghetto Silvana Schwerz
Laboratory of Molecular Analysis, Faculty of Ceilândia, Universidade de Brasília, Brasilia 70910-900, Brazil.
Graduate Program of Sciences and Technology of Health, Faculty of Ceilândia, Universidade de Brasília, Brasilia 70910-900, Brazil.
Biology (Basel). 2022 Mar 31;11(4):537. doi: 10.3390/biology11040537.
This study aimed to evaluate the time course and responsiveness of plasma interleukin-6 (IL-6) and creatine kinase (CK) levels following acute eccentric resistance exercise in sedentary obese older women with a different muscle quality index (MQI). Eighty-eight participants (69.4 ± 6.06 years) completed an acute eccentric resistance exercise (7 sets of 10 repetitions at 110% of 10-repetition maximum with 3 min rest interval). Participants were divided into two groups: high or low MQI according to 50th percentile cut-off. The responsiveness was based on minimal clinical important difference. There were no differences between groups and time on IL-6 and CK levels (p > 0.05). However, the high MQI group displayed a lower proportion of low responders (1 for laboratory and 2 for field-based vs. 5 and 4) and a higher proportion of high responders for IL-6 (7 for laboratory and 6 for field-based vs. 4 and 5) compared to low MQI group. In addition, the high MQI group showed a higher proportion of high responders for CK (11 for laboratory and 9 for field-based vs. 6 and 6) compared to low MQI. A prior MQI screening can provide feedback to understand the magnitude response. Individual responsiveness should be taken into consideration for maximizing eccentric exercise prescription.
本研究旨在评估不同肌肉质量指数（MQI）的久坐肥胖老年女性在进行急性离心阻力运动后血浆白细胞介素-6（IL-6）和肌酸激酶（CK）水平的时间进程和反应性。88名参与者（69.4±6.06岁）完成了一次急性离心阻力运动（7组，每组10次重复，强度为10次重复最大值的110%，休息间隔3分钟）。参与者根据第50百分位数切点分为两组：高MQI组或低MQI组。反应性基于最小临床重要差异。两组在IL-6和CK水平上的组间和时间差异均无统计学意义（p>0.05）。然而，与低MQI组相比，高MQI组低反应者的比例较低（实验室检测为1例，现场检测为2例，而低MQI组分别为5例和4例），IL-6高反应者的比例较高（实验室检测为7例，现场检测为6例，而低MQI组分别为4例和5例）。此外，与低MQI组相比，高MQI组CK高反应者的比例更高（实验室检测为11例，现场检测为9例，而低MQI组分别为6例和6例）。预先进行MQI筛查可以提供反馈，以了解反应程度。为了使离心运动处方最大化，应考虑个体反应性。
