Turgut Ali Osman, Küçük Mürsel, Irmak Mehmet, Özcan Cahit, Koca Davut, Gülendağ Erman, Önen Muhammed Furkan, Doğan Rahmi, Ünver Ali, Keskin İbrahim Halil
Department of Animal Science, Faculty of Veterinary Medicine, Siirt University, Siirt, Turkey.
Department of Animal Nutrition and Nutritional Disease, Faculty of Veterinary Medicine, Siirt University, Siirt, Turkey.
Vet Med Sci. 2025 May;11(3):e70259. doi: 10.1002/vms3.70259.
Pregnancy toxemia (PT) is a common metabolic disorder that occurs in the last trimester of pregnancy. This study aimed to detect the effects of subclinical PT (SPT) on serum biochemical parameters of ewes and postnatal growth and development of lambs in Romanov sheep. A total of 40 ewes and 69 lambs were included in the study. Blood samples of ewes were collected at the time of parturition to evaluate serum beta-hydroxybutyric acid (βHBA), serum nonesterified fatty acid (NEFA), cholesterol, and triglyceride. Live weight and body measurements of lambs were recorded at birth (0th day), 30th day, and 60th (weaning) day. In the diagnosis of SPT serum βHBA concentrations were taken into account. A cut-off value of 0.8 mmol/L for βHBA was a critical concentration and ewes with 0.8-1.6 mmol/L βHBA were evaluated as SPT. There were no ewes with ΒHBA value higher than 1.6 mmol/L (clinical PT) in the study. There was no significant difference in serum βHBA, NEFA and cholesterol concentrations between ewes regarding birth type (single, twin, and triplet). However, triglyceride concentrations were higher (p < 0.001) in ewes giving birth to triplets compared to ewes giving birth to single lamb. Serum βHBA and triglyceride concentrations were higher (p < 0.01) in ewes with SPT (n = 14) compared to healthy ewes (n = 26). There was no significant difference between ewes with SPT and healthy ewes in serum NEFA and cholesterol. Repeated measures ANOVA results indicated that SPT negatively affected 0th, 30th, and 60th body weights of twin (p < 0.01) and triplet born lambs (p < 0.05). The effect of time on body weights was also found to be significant (p < 0.001). Similarly, most of the body measurements of twin and triplet born lambs were lower (p < 0.05) in the SPT group compared to healthy group. Overall results indicate that SPT may negatively affect postnatal growth and development in Romanov lambs. Because a decline in growth performance has many negative outcomes affecting production traits in sheep, these findings may be valuable for the veterinary field.
妊娠毒血症（PT）是一种常见的代谢紊乱疾病，发生在妊娠晚期。本研究旨在检测亚临床妊娠毒血症（SPT）对罗曼诺夫绵羊母羊血清生化参数以及羔羊出生后生长发育的影响。本研究共纳入40只母羊和69只羔羊。在分娩时采集母羊血液样本，以评估血清β-羟基丁酸（βHBA）、血清非酯化脂肪酸（NEFA）、胆固醇和甘油三酯水平。记录羔羊出生时（第0天）、第30天和第60天（断奶）的体重和体尺。在SPT的诊断中，考虑了血清βHBA浓度。βHBA的临界值为0.8 mmol/L，βHBA浓度在0.8 - 1.6 mmol/L之间的母羊被评估为患有SPT。本研究中没有βHBA值高于1.6 mmol/L的母羊（临床PT）。母羊的血清βHBA、NEFA和胆固醇浓度在出生类型（单胎、双胎和三胎）方面没有显著差异。然而，与单胎母羊相比，三胎母羊的甘油三酯浓度更高（p < 0.001）。与健康母羊（n = 26）相比，患有SPT的母羊（n = 14）血清βHBA和甘油三酯浓度更高（p < 0.01）。患有SPT的母羊与健康母羊在血清NEFA和胆固醇方面没有显著差异。重复测量方差分析结果表明，SPT对双胎（p < 0.01）和三胎羔羊出生时、第30天和第60天的体重有负面影响（p < 0.05）。时间对体重的影响也很显著（p < 0.001）。同样，与健康组相比，SPT组双胎和三胎羔羊的大多数体尺测量值较低（p < 0.05）。总体结果表明，SPT可能对罗曼诺夫羔羊出生后的生长发育产生负面影响。由于生长性能下降会对绵羊的生产性状产生许多负面结果，这些发现可能对兽医领域有价值。
