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CoA in Health and Disease.《健康与疾病中的 CoA》
Int J Mol Sci. 2022 Apr 15;23(8):4371. doi: 10.3390/ijms23084371.
2
Coenzyme A, protein CoAlation and redox regulation in mammalian cells.辅酶 A、蛋白质共沉淀和哺乳动物细胞中的氧化还原调节。
Biochem Soc Trans. 2018 Jun 19;46(3):721-728. doi: 10.1042/BST20170506. Epub 2018 May 25.
3
Effects of propionate and carnitine on the hepatic oxidation of short- and medium-chain-length fatty acids.丙酸酯和肉碱对短链及中链脂肪酸肝脏氧化的影响。
Biochem J. 1988 Mar 15;250(3):819-25. doi: 10.1042/bj2500819.
4
Aspects of ketogenesis: control and mechanism of ketone-body formation in isolated rat-liver mitochondria.生酮作用的各个方面：大鼠离体肝脏线粒体中酮体生成的调控与机制
Mol Cell Biochem. 1975 Dec 31;9(3):155-73. doi: 10.1007/BF01751311.
5
Protein CoAlation: a redox-regulated protein modification by coenzyme A in mammalian cells.蛋白质辅酶A化：哺乳动物细胞中由辅酶A介导的一种氧化还原调节的蛋白质修饰
Biochem J. 2017 Jul 11;474(14):2489-2508. doi: 10.1042/BCJ20170129.
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A possible role for malonyl-CoA in the regulation of hepatic fatty acid oxidation and ketogenesis.丙二酰辅酶A在肝脏脂肪酸氧化和酮体生成调节中的可能作用。
J Clin Invest. 1977 Jul;60(1):265-70. doi: 10.1172/JCI108764.
7
Coenzyme A levels influence protein acetylation, CoAlation and 4'-phosphopantetheinylation: Expanding the impact of a metabolic nexus molecule.辅酶 A 水平影响蛋白质乙酰化、共酰化和 4'-磷酸泛酰巯基乙胺化：扩大代谢枢纽分子的影响。
Biochim Biophys Acta Mol Cell Res. 2021 Apr;1868(4):118965. doi: 10.1016/j.bbamcr.2021.118965. Epub 2021 Jan 13.
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A single therapeutic dose of valproate affects liver carbohydrate, fat, adenylate, amino acid, coenzyme A, and carnitine metabolism in infant mice: possible clinical significance.单次治疗剂量的丙戊酸盐会影响幼鼠的肝脏碳水化合物、脂肪、腺苷酸、氨基酸、辅酶A和肉碱代谢：可能的临床意义。
Life Sci. 1985 Apr 29;36(17):1643-51. doi: 10.1016/0024-3205(85)90367-4.
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Coenzyme A and its derivatives: renaissance of a textbook classic.辅酶A及其衍生物：教科书经典的复兴
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Enzymatic regulation of liver acetyl-CoA metabolism in relation to ketogenesis.肝脏乙酰辅酶A代谢与酮体生成相关的酶促调节
Adv Enzyme Regul. 1964;2:85-99. doi: 10.1016/s0065-2571(64)80007-8.

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Metabolic Characteristics of Obese Adolescents with Different Degrees of Weight Loss After Identical Exercise Training Intervention.相同运动训练干预后不同减重程度肥胖青少年的代谢特征
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Impaired mitochondrial integrity and compromised energy production underscore the mechanism underlying CoASY protein-associated neurodegeneration.线粒体完整性受损和能量产生受损突出了CoASY蛋白相关神经变性的潜在机制。
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Mesenchymal Stem Cell-Derived Mitochondria Enhance Extracellular Matrix-Derived Grafts for the Repair of Nerve Defect.间充质干细胞来源的线粒体增强细胞外基质衍生移植物用于修复神经缺损
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本文引用的文献

1
Regulation of the CoA Biosynthetic Complex Assembly in Mammalian Cells.调节哺乳动物细胞中的 CoA 生物合成复合物组装
Int J Mol Sci. 2021 Jan 24;22(3):1131. doi: 10.3390/ijms22031131.
2
Monounsaturated Fatty Acids in Obesity-Related Inflammation.肥胖相关炎症中的单不饱和脂肪酸
Int J Mol Sci. 2020 Dec 30;22(1):330. doi: 10.3390/ijms22010330.
3
Exploring Yeast as a Study Model of Pantothenate Kinase-Associated Neurodegeneration and for the Identification of Therapeutic Compounds.探讨酵母作为泛酸激酶相关神经退行性疾病的研究模型及治疗化合物的鉴定。
Int J Mol Sci. 2020 Dec 30;22(1):293. doi: 10.3390/ijms22010293.
4
Interplay between Thyroid Hormones and Stearoyl-CoA Desaturase 1 in the Regulation of Lipid Metabolism in the Heart.甲状腺激素与硬脂酰辅酶 A 去饱和酶 1 在心脏脂质代谢调控中的相互作用。
Int J Mol Sci. 2020 Dec 24;22(1):109. doi: 10.3390/ijms22010109.
5
Neuronal Ablation of CoA Synthase Causes Motor Deficits, Iron Dyshomeostasis, and Mitochondrial Dysfunctions in a CoPAN Mouse Model.在CoPAN小鼠模型中，辅酶A合成酶的神经元消融导致运动功能障碍、铁稳态失调和线粒体功能障碍。
Int J Mol Sci. 2020 Dec 19;21(24):9707. doi: 10.3390/ijms21249707.
6
The Pathophysiological Role of CoA.辅酶 A 的病理生理学作用。
Int J Mol Sci. 2020 Nov 28;21(23):9057. doi: 10.3390/ijms21239057.
7
Changes of Coenzyme A and Acetyl-Coenzyme A Concentrations in Rats after a Single-Dose Intraperitoneal Injection of Hepatotoxic Thioacetamide Are Not Consistent with Rapid Recovery.单次腹腔注射肝毒性硫代乙酰胺后大鼠辅酶 A 和乙酰辅酶 A 浓度的变化与快速恢复不一致。
Int J Mol Sci. 2020 Nov 24;21(23):8918. doi: 10.3390/ijms21238918.
8
Stearoyl-CoA Desaturase-2 in Murine Development, Metabolism, and Disease.硬脂酰辅酶 A 去饱和酶-2 在小鼠发育、代谢和疾病中的作用。
Int J Mol Sci. 2020 Nov 16;21(22):8619. doi: 10.3390/ijms21228619.
9
How Elongator Acetylates tRNA Bases.延伸酶如何乙酰化 tRNA 碱基。
Int J Mol Sci. 2020 Nov 3;21(21):8209. doi: 10.3390/ijms21218209.
10
Stearoyl-CoA Desaturase 1 Activity Determines the Maintenance of DNMT1-Mediated DNA Methylation Patterns in Pancreatic β-Cells.硬脂酰辅酶 A 去饱和酶 1 活性决定了胰腺β细胞中 DNMT1 介导的 DNA 甲基化模式的维持。
Int J Mol Sci. 2020 Sep 18;21(18):6844. doi: 10.3390/ijms21186844.

《健康与疾病中的 CoA》

CoA in Health and Disease.

机构信息

Laboratory of Molecular Medical Biochemistry, Nencki Institute of Experimental Biology, Polish Academy of Sciences, 02-093 Warsaw, Poland.

出版信息

Int J Mol Sci. 2022 Apr 15;23(8):4371. doi: 10.3390/ijms23084371.

DOI:10.3390/ijms23084371
PMID:35457189
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9026968/
Abstract

Coenzyme A (CoA) and its thioester derivatives are crucial components of numerous biosynthetic and degradative pathways of the cellular metabolism (including fatty acid synthesis and oxidation, the Krebs cycle, ketogenesis, cholesterol and acetylcholine biosynthesis, amino acid degradation, and neurotransmitter biosynthesis), post-translational modifications of proteins, and the regulation of gene expression [...].

摘要

辅酶 A（CoA）及其硫酯衍生物是细胞代谢中许多生物合成和降解途径（包括脂肪酸合成和氧化、三羧酸循环、酮体生成、胆固醇和乙酰胆碱合成、氨基酸降解以及神经递质合成）、蛋白质的翻译后修饰以及基因表达调控的关键组成部分[... ]。