血清 25-羟胆钙化醇水平降低与巴西南部老年人的抑郁症状有关。
Lower serum 25-hydroxycholecalciferol is associated with depressive symptoms in older adults in Southern Brazil.
机构信息
Postgraduate Program in Nutrition, Federal University of Santa Catarina, Florianopolis, Brazil.
Postgraduate Program in Public Health, Federal University of Maranhão, Maranhão, Brazil.
出版信息
Nutr J. 2020 Nov 14;19(1):123. doi: 10.1186/s12937-020-00638-5.
BACKGROUND
Older adults are one of the most susceptible populations to depression, especially those living in low- and middle-income countries. As well, they are also considering a risk group for vitamin D deficiency. Low serum vitamin D has been associated with an increased risk of brain neuropsychiatry disorders. We aimed to investigate the association between serum 25-hydroxycholecalciferol concentrations and depressive symptoms in adults aged 60 years and over from southern Brazil.
METHODS
A cross-sectional analysis was performed using data collected during 2013-2014 from the populational-based longitudinal EpiFloripa Aging Study (n = 1197). Serum 25-hydroxycholecalciferol concentrations were analyzed and classified according to the Endocrine Society reference values [sufficiency (≥ 30 ng/mL), insufficiency (21-29 ng/mL), and deficiency (≤ 20 ng/mL)]. Depressive symptoms were evaluated using the Geriatric Depression Scale (15-item GDS). Logistic regression was performed to assess depressive symptoms in each vitamin D category. The analysis was adjusted for sex, age, skin color, family income, leisure-time physical activities, social or religious groups attendance, morbidities, cognitive impairment, and dependence in activities of daily living.
RESULTS
A total of 557 participants with complete data for exposure and outcome were enrolled in the analysis. Most of the sample participants were female (63.1%), age-range 60-69 years (42.2%), white skin color (85.1%), and vitamin D serum level samples were collected in autumn (50.7%). Depressive symptoms were present in 15.8% of the participants, and the prevalence was higher in individuals classified as deficient in vitamin D (23.2, 95% confidence interval [CI] = 15.6;32.9) and insufficiency (17.2, 95%CI = 11.0;25.9). The crude analysis showed that vitamin D deficient participants had 3.08 (CI = 1.53;6.20) times higher odds to present depressive symptoms compared to vitamin D sufficiency. After adjusting, the association was maintained [OR 2.27 (95%CI = 1.05;4.94).
CONCLUSIONS
Serum 25-hydroxycholecalciferol deficiency was positively associated with depressive symptoms in older adults from southern Brazil.
背景
老年人是最易患抑郁症的人群之一，尤其是生活在中低收入国家的老年人。此外，他们也是维生素 D 缺乏的高危人群。血清维生素 D 水平较低与大脑神经精神疾病的风险增加有关。我们旨在研究巴西南部 60 岁及以上成年人血清 25-羟胆钙化醇浓度与抑郁症状之间的关系。
方法
使用 2013-2014 年基于人群的纵向 EpiFloripa 衰老研究（n=1197）的数据进行了横断面分析。根据内分泌学会的参考值[充足（≥30ng/mL）、不足（21-29ng/mL）和缺乏（≤20ng/mL）]分析血清 25-羟胆钙化醇浓度并进行分类。使用老年抑郁量表（15 项 GDS）评估抑郁症状。使用逻辑回归评估每个维生素 D 类别中的抑郁症状。分析调整了性别、年龄、肤色、家庭收入、休闲时间体育活动、参加社会或宗教团体、发病情况、认知障碍和日常生活活动的依赖。
结果
共有 557 名暴露和结局数据完整的参与者纳入分析。样本中大多数参与者为女性（63.1%），年龄在 60-69 岁（42.2%），肤色为白色（85.1%），血清维生素 D 水平样本采集于秋季（50.7%）。15.8%的参与者存在抑郁症状，维生素 D 缺乏组的患病率较高（23.2%，95%置信区间[CI]=15.6%；32.9%）和不足组（17.2%，95%CI=11.0%；25.9%）。初步分析显示，与维生素 D 充足者相比，维生素 D 缺乏者出现抑郁症状的可能性高 3.08 倍（CI=1.53；6.20）。调整后，这种关联仍然存在[比值比 2.27（95%CI=1.05；4.94）]。
结论
血清 25-羟胆钙化醇缺乏与巴西南部老年人的抑郁症状呈正相关。
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