慢性病毒性肝炎的纤维化分期。
Staging Fibrosis in Chronic Viral Hepatitis.
机构信息
Postgraduate Internal Medicine Program, Hepatology Division, Clementino Fraga Filho University Hospital, School of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro 21941-617, Brazil.
Hepatology Division, General Hospital, Santa Casa da Misericórdia do Rio de Janeiro, Rio de Janeiro 20020-022, Brazil.
出版信息
Viruses. 2022 Mar 23;14(4):660. doi: 10.3390/v14040660.
Abstract
Staging fibrosis accurately has always been a challenge in viral hepatitis and other liver diseases. Liver biopsy is an imperfect gold standard due to its intra and interobserver agreement limitations and additional characteristics such as its safety and cost. Hence, non-invasive tests have been developed to stage liver fibrosis. In addition to serological biomarkers, physical tests with reasonable accuracy are available and adopted in the daily clinic regarding viral hepatitis fibrosis staging. In this review, we discuss the published data regarding the staging of liver fibrosis in chronic hepatitis B and C, emphasizing non-invasive markers of fibrosis, both serological and physical. Moreover, we also discuss a persistent central gap, the evaluation of liver fibrosis after HCV cure.
摘要
准确分期纤维化一直是病毒性肝炎和其他肝脏疾病的挑战。由于肝活检的观察者内和观察者间一致性存在局限性，以及其安全性和成本等其他特征，肝活检并不是一种完美的金标准。因此，已经开发了非侵入性试验来分期纤维化。除了血清生物标志物外，针对病毒性肝炎纤维化分期，在日常临床实践中还采用了具有合理准确性的物理检测。在这篇综述中，我们讨论了关于慢性乙型和丙型肝炎肝纤维化分期的已发表数据，重点介绍了纤维化的非侵入性标志物，包括血清学和物理学标志物。此外，我们还讨论了一个持续存在的中心差距，即 HCV 治愈后对肝纤维化的评估。
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