AgResearch Ltd., Hopkirk Research Institute, Massey University, Corner University Ave and Library Road, Palmerston North 4442, New Zealand.
School of Veterinary Science, Massey University Manawatu (Turitea), Tennent Drive, Palmerston North 4474, New Zealand.
Viruses. 2021 Jul 23;13(8):1436. doi: 10.3390/v13081436.
Transmission of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) occurs through respiratory droplets passed directly from person to person or indirectly through fomites, such as common use surfaces or objects. The aim of this study was to determine the virucidal efficacy of blue LED (405 nm) and far-UVC (222 nm) light in comparison to standard UVC (254 nm) irradiation for the inactivation of feline infectious peritonitis virus (FIPV) on different matrices as a model for SARS-CoV-2. Wet or dried FIPV on stainless steel, plastic, or paper discs, in the presence or absence of artificial saliva, were exposed to various wavelengths of light for different time periods (1-90 min). Dual activity of blue LED and far-UVC lights were virucidal for most wet and dried FIPV within 4 to 16 min on all matrices. Individual action of blue LED and far-UVC lights were virucidal for wet FIPV but required longer irradiation times (8-90 min) to reach a 4-log reduction. In comparison, LED (265 nm) and germicidal UVC (254 nm) were virucidal on almost all matrices for both wet and dried FIPV within 1 min exposure. UVC was more effective for the disinfection of surfaces as compared to blue LED and far-UVC individually or together. However, dual action of blue LED and far-UVC was virucidal. This combination of lights could be used as a safer alternative to traditional UVC.
严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 通过人与人之间直接传播的呼吸道飞沫或通过常见使用表面或物体间接传播的飞沫传播。本研究的目的是确定蓝紫光 LED（405nm）和远紫外 C（222nm）光在灭活猫传染性腹膜炎病毒（FIPV）方面与标准紫外 C（254nm）照射相比，对不同基质（作为 SARS-CoV-2 的模型）的病毒杀灭效果。湿或干 FIPV 在不锈钢、塑料或纸盘上，存在或不存在人工唾液的情况下，暴露于不同波长的光下不同时间（1-90 分钟）。在所有基质上，蓝紫光 LED 和远紫外 C 光的双重作用在 4 到 16 分钟内对大多数湿和干 FIPV 具有病毒杀灭作用。蓝紫光 LED 和远紫外 C 光的单独作用对湿 FIPV 具有病毒杀灭作用，但需要更长的照射时间（8-90 分钟）才能达到 4 对数减少。相比之下，LED（265nm）和杀菌紫外 C（254nm）在 1 分钟的暴露时间内，对湿和干 FIPV 在几乎所有基质上均具有病毒杀灭作用。与蓝紫光 LED 和远紫外 C 单独或联合使用相比，UVC 更适合用于表面消毒。然而，蓝紫光 LED 和远紫外 C 的双重作用具有病毒杀灭作用。这种光的组合可以作为传统紫外 C 的更安全替代方案。
