Chemes H E, Carizza C, Scarinci F, Brugo S, Neuspiller N, Schwarsztein L
Fertil Steril. 1987 Feb;47(2):310-6. doi: 10.1016/s0015-0282(16)50011-9.
Three patients with primary sterility in whom the majority of spermatozoa lacked a normally implanted head are presented. A small cephalic knob was evident in most of them by routine colorimetric techniques, and the Feulgen reaction failed to show any deoxyribose nucleic acid. The morphologic features of the tails was normal. Few loose sperm heads were observed in the ejaculates. Even though motility was decreased, there were numerous acephalic sperms with different degrees of forward motility. Electron microscopy showed a well-organized structure of the centrioles and connecting piece, which were located in the neck region within a small cytoplasmic mass, but no chromatin was detected in any case. Studies on immature spermatids present in semen evidenced an independent anomalous development of heads and tails and suggested that they became separated at the end of spermatid maturation. This anomaly, of probable genetic origin, is interpreted to be due either to an alteration in the mechanism of migration and positioning of the tail on the caudal pole of the nucleus or to an interference with the formation of the implantation fossa of the head, which normally accommodates the connecting piece.
本文报告了3例原发性不育患者，其大多数精子头部植入异常。通过常规比色技术，在大多数患者中可见一个小的头部小结，福尔根反应未显示任何脱氧核糖核酸。尾部的形态特征正常。在射精物中观察到少量游离的精子头部。尽管活力下降，但仍有许多无头精子具有不同程度的向前运动能力。电子显微镜显示中心粒和连接段结构良好，位于颈部区域的一小团细胞质内，但在任何情况下均未检测到染色质。对精液中未成熟精子细胞的研究表明，头部和尾部存在独立的异常发育，并提示它们在精子细胞成熟末期分离。这种异常可能源于遗传，被解释为要么是尾部在细胞核尾极的迁移和定位机制发生改变，要么是头部植入窝的形成受到干扰，而植入窝通常容纳连接段。
