Fujian Provincial Sleep-Disordered Breathing Clinic Center, Institute of Respiratory Disease, Fujian Medical University, NO 20, Chazhong Road, Taijiang District, Fuzhou, Fujian Province, 350005, People's Republic of China.
Department of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Fujian Medical University, NO 20, Chazhong Road, Taijiang District, Fuzhou, Fujian Province, 350005, People's Republic of China.
Sleep Breath. 2023 Mar;27(1):363-369. doi: 10.1007/s11325-022-02617-y. Epub 2022 Apr 23.
The cause of benign prostatic hyperplasia (BPH) is controversial, local hypoxia and inflammation being the main two possibilities proposed. The aim of this study was to evaluate the relationship between obstructive sleep apnea (OSA) and BPH.
The study cohort comprised men from January 2016 to December 2020 in our Sleep Center. These patients were classified into four groups (no, mild, moderate, severe OSA) by apnea-hypopnea indexes (AHI). Logistic regression was used to identify independent risk factors for BPH, after which participants were stratified into younger (age ≤ 40 years) and older groups (age > 40 years) for further analysis.
The study cohort comprised 467 patients including 135 younger subjects and 332 older subjects. The prevalence of BPH in the above listed AHI categories was 37.5%, 55.0%, 62.9%, and 52.3%, respectively (p = 0.075). Logistic regression analysis of all patients identified age as a risk factor for BPH (p < 0.001). Stratified analysis according to AHI category found a prevalence of BPH of 0.0%, 13.0%, 33.3%, and 43.9%, respectively, in younger group (p = 0.006), and 52.2%, 71.9%, 71.1%, and 56.3%, respectively, in older group (p = 0.038). Logistic regression analysis found age and AHI were independent risk factors for BPH in younger group (both p < 0.05), whereas only age was identified as a risk factor for BPH in older group (p < 0.001).
Age is an independent risk factor for BPH in men with OSA. AHI is also an independent risk factor for BPH in younger men, suggesting that OSA may affect development of BPH in younger men.
良性前列腺增生（BPH）的病因尚存在争议，局部缺氧和炎症是主要的两种可能性。本研究旨在评估阻塞性睡眠呼吸暂停（OSA）与 BPH 之间的关系。
本研究队列纳入了 2016 年 1 月至 2020 年 12 月期间在我院睡眠中心就诊的男性患者。根据呼吸暂停低通气指数（AHI），将这些患者分为四组（无、轻度、中度、重度 OSA）。采用 logistic 回归分析识别 BPH 的独立危险因素，然后将患者分为年龄≤40 岁和年龄>40 岁的两组进行进一步分析。
本研究队列共纳入 467 例患者，其中年龄≤40 岁 135 例，年龄>40 岁 332 例。上述 AHI 分组中 BPH 的患病率分别为 37.5%、55.0%、62.9%和 52.3%（p=0.075）。对所有患者进行 logistic 回归分析发现，年龄是 BPH 的危险因素（p<0.001）。根据 AHI 分类进行分层分析发现，年龄≤40 岁组的 BPH 患病率分别为 0.0%、13.0%、33.3%和 43.9%（p=0.006），年龄>40 岁组分别为 52.2%、71.9%、71.1%和 56.3%（p=0.038）。logistic 回归分析发现，年龄和 AHI 是年龄≤40 岁组 BPH 的独立危险因素（均 p<0.05），而年龄是年龄>40 岁组 BPH 的唯一独立危险因素（p<0.001）。
年龄是 OSA 男性发生 BPH 的独立危险因素。AHI 也是年龄≤40 岁男性发生 BPH 的独立危险因素，提示 OSA 可能影响年轻男性 BPH 的发生发展。
