Metta Ramesh V V S, Zaka Awais, Lee Vincent C, Mador M Jeffery
The Veterans Affairs Western New York Healthcare System, University at Buffalo, 3495 Bailey Avenue, Buffalo, NY, 14215, USA.
Division of Pulmonary, Critical Care, and Sleep Medicine, University at Buffalo, 3495 Bailey Avenue, Buffalo, NY, 14215, USA.
Lung. 2017 Apr;195(2):255-261. doi: 10.1007/s00408-017-9981-9. Epub 2017 Feb 16.
Purpose To determine the short-term and long-term adherence rates with continuous positive airway pressure (CPAP) therapy in sleep apnea patients with benign prostatic hyperplasia (BPH) compared to matched controls. Methods A case-control retrospective analysis was performed in a veterans affairs hospital. All symptomatic patients with BPH (n = 107) ever started on CPAP therapy between 2006 and 2012 were compared with controls matched for severity of sleep apnea (AHI). Adherence measures were obtained at the third and twelfth month visits. The cases included symptomatic BPH patients on active medical therapy. Diuretic use among cases and controls, and severity of nocturia among the cases were also analyzed. Results The mean AHI among cases and controls was 35.6 ± 27.3 and 35.5 ± 31 (p = 0.96). The population was male and predominantly Caucasian. There was no statistically significant difference in percent days CPAP device use ≥4 h. between symptomatic BPH patients and controls at 3-month (51.6 ± 38 vs. 47.2 ± 36; p = 0.43) and 1-year (64 ± 40.5 vs. 64.7 ± 31.3; p = 0.90) visits. The use of diuretics in the cases and controls, and the severity of nocturia in the cases did not influence adherence with CPAP therapy. Conclusions BPH or diuretic use did not affect adherence with CPAP therapy in obstructive sleep apnea. Severity of nocturia did not have any influence on adherence among the cases. BPH, regardless of the severity of nocturia, and diuretic use does not influence CPAP adherence in patients with OSA.
目的 确定与匹配的对照组相比，患有良性前列腺增生（BPH）的睡眠呼吸暂停患者持续气道正压通气（CPAP）治疗的短期和长期依从率。方法 在一家退伍军人事务医院进行病例对照回顾性分析。将2006年至2012年间开始接受CPAP治疗的所有有症状的BPH患者（n = 107）与根据睡眠呼吸暂停严重程度（呼吸暂停低通气指数，AHI）匹配的对照组进行比较。在第三次和第十二个月就诊时获取依从性测量值。病例包括接受积极药物治疗的有症状BPH患者。还分析了病例组和对照组中利尿剂的使用情况以及病例组中夜尿症的严重程度。结果 病例组和对照组的平均AHI分别为35.6±27.3和35.5±31（p = 0.96）。研究人群为男性，主要是白种人。在3个月时（51.6±38 vs. 47.2±36；p = 0.43）和1年时（64±40.5 vs. 64.7±31.3；p = 0.90），有症状的BPH患者与对照组之间CPAP设备使用≥4小时的天数百分比没有统计学上的显著差异。病例组和对照组中利尿剂的使用以及病例组中夜尿症的严重程度均未影响CPAP治疗的依从性。结论 BPH或利尿剂的使用不会影响阻塞性睡眠呼吸暂停患者对CPAP治疗的依从性。夜尿症的严重程度对病例组的依从性没有任何影响。无论夜尿症的严重程度如何，BPH和利尿剂的使用均不影响阻塞性睡眠呼吸暂停患者的CPAP依从性。
