Division of Pulmonary and Critical Care Medicine, Mackay Memorial Hospital, Taipei City, Taiwan.
Department of Radiology, Mackay Memorial Hospital, Taipei City, Taiwan.
BMC Med Imaging. 2022 Apr 23;22(1):76. doi: 10.1186/s12880-022-00803-8.
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a disease that primarily occurs in elderly individuals. However, it is difficult to diagnose and has a complex disease course. High-resolution computed tomography (HRCT) and lung function testing are crucial for its diagnosis and follow-up. However, the correlation of HRCT findings with lung function test results has not been extensively investigated. METHODS: This study retrospectively analysed the medical records and images of patients with IPF. Patients with evident emphysema and lung cancer were excluded. The diagnosis of all the included cases was confirmed following a discussion among specialists from multiple disciplines. The correlation of HRCT findings, including fibrotic score, HRCT lung volume, pulmonary artery trunk (PA) diameter and pulmonary vascular volume (PVV), with lung function test parameters, such as forced vital capacity (FVC) and diffusing capacity for carbon monoxide (DLCO), was analysed. RESULTS: A total of 32 patients were included. Higher fibrotic and PVV scores were significantly correlated with lower DLCO (r = - 0.59, p = 0.01; r = - 0.43, p = 0.03, respectively) but not with FVC. Higher PVV score significantly correlated with higher fibrotic score (r = 0.59, p < 0.01) and PA diameter (r = 0.47, p = 0.006). CONCLUSION: Our study demonstrated the structural and functional correlation of IPF. The extent of lung fibrosis (fibrotic score) and PVV score were associated with DLCO but not with FVC. The PA diameter, which reflects the pulmonary artery pressure, was found to be associated with the PVV score.
背景：特发性肺纤维化（IPF）是一种主要发生在老年人中的疾病。然而，它的诊断较为困难，且疾病进程复杂。高分辨率计算机断层扫描（HRCT）和肺功能测试对其诊断和随访至关重要。然而，HRCT 结果与肺功能测试结果的相关性尚未得到广泛研究。
方法：本研究回顾性分析了 IPF 患者的病历和影像资料。排除了明显肺气肿和肺癌的患者。所有纳入病例的诊断均在多学科专家讨论后得到确认。分析了 HRCT 结果（包括纤维化评分、HRCT 肺容积、肺动脉干（PA）直径和肺血管容积（PVV））与肺功能测试参数（如用力肺活量（FVC）和一氧化碳弥散量（DLCO））之间的相关性。
结果：共纳入 32 例患者。较高的纤维化和 PVV 评分与较低的 DLCO 显著相关（r= -0.59，p=0.01；r= -0.43，p=0.03），但与 FVC 无关。较高的 PVV 评分与较高的纤维化评分（r=0.59，p<0.01）和 PA 直径（r=0.47，p=0.006）显著相关。
结论：本研究表明了特发性肺纤维化的结构和功能相关性。肺纤维化程度（纤维化评分）和 PVV 评分与 DLCO 相关，而与 FVC 无关。反映肺动脉压力的 PA 直径与 PVV 评分相关。
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