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印度自我报告糖尿病患者达到指南推荐的糖尿病治疗目标和健康习惯的情况(ICMR-INDIAB-13):一项全国性横断面研究。

Achievement of guideline recommended diabetes treatment targets and health habits in people with self-reported diabetes in India (ICMR-INDIAB-13): a national cross-sectional study.

机构信息

Department of Diabetology, Madras Diabetes Research Foundation, Indian Council of Medical Research Centre for Advanced Research on Diabetes and Dr Mohan's Diabetes Specialities Centre, Chennai, India.

Department of Epidemiology, Madras Diabetes Research Foundation, Indian Council of Medical Research Centre for Advanced Research on Diabetes and Dr Mohan's Diabetes Specialities Centre, Chennai, India.

出版信息

Lancet Diabetes Endocrinol. 2022 Jun;10(6):430-441. doi: 10.1016/S2213-8587(22)00072-9. Epub 2022 Apr 21.

Abstract

BACKGROUND

There is little information on comprehensive diabetes care comprising glycaemic, lipid, and blood pressure control in India; therefore, we aimed to assess the achievement of treatment targets among adults with self-reported diabetes.

METHODS

The Indian Council of Medical Research (ICMR)-India Diabetes (INDIAB) study is a cross-sectional, population-based survey of adults aged 20 years or older in all 30 states and union territories of India. We used a stratified multistage sampling design, sampling states in a phased manner, and selected villages in rural areas and census enumeration blocks in urban areas. We used a three-level stratification method on the basis of geography, population size, and socioeconomic status for each state. For the outcome assessment, good glycaemic control was defined as HbA of less than 7·0% (A), blood pressure control was defined as less than 140/90 mm Hg (B), and the LDL cholesterol target was defined as less than 100 mg/dL (C). ABC control was defined as the proportion of individuals meeting glycaemic, blood pressure, and LDL cholesterol targets together. We also performed multiple logistic regression to assess the factors influencing achievement of diabetes treatment targets.

FINDINGS

Between Oct 18, 2008, and Dec 17, 2020, 113 043 individuals (33 537 from urban areas and 79 506 from rural areas) participated in the ICMR-INDIAB study. For this analysis, 5789 adults (2633 in urban areas and 3156 in rural areas) with self-reported diabetes were included in the study population. The median age was 56·1 years (IQR 55·7-56·5). Overall, 1748 (weighted proportion 36·3%, 95% CI 34·7-37·9) of 4834 people with diabetes achieved good glycaemic control, 2819 (weighted proportion 48·8%, 47·2-50·3) of 5698 achieved blood pressure control, and 2043 (weighted proportion 41·5%, 39·9-43·1) of 4886 achieved good LDL cholesterol control. Only 419 (weighted proportion 7·7%) of 5297 individuals with self-reported diabetes achieved all three ABC targets, with significant heterogeneity between regions and states. Higher education, male sex, rural residence, and shorter duration of diabetes (<10 years) were associated with better achievement of combined ABC targets. Only 951 (weighted proportion 16·7%) of the study population and 227 (weighted proportion 36·9%) of those on insulin reported using self-monitoring of blood glucose.

INTERPRETATION

Achievement of treatment targets and adoption of healthy behaviours remains suboptimal in India. Our results can help governments to adopt policies that prioritise improvement of diabetes care delivery and surveillance in India.

FUNDING

Indian Council of Medical Research and Department of Health Research, Ministry of Health and Family Welfare.

摘要

背景

印度在包括血糖、血脂和血压控制在内的综合糖尿病治疗方面的信息有限;因此,我们旨在评估有自我报告糖尿病的成年人实现治疗目标的情况。

方法

印度医学研究理事会(ICMR)-印度糖尿病(INDIAB)研究是一项横断面、基于人群的调查,对象为印度所有 30 个邦和联邦属地的 20 岁及以上成年人。我们使用分层多阶段抽样设计,分阶段抽样各州,并在农村地区选择村庄,在城市地区选择人口普查区。我们根据地理位置、人口规模和社会经济地位对每个州进行了三级分层方法。对于结局评估,良好的血糖控制定义为 HbA <7.0%(A),血压控制定义为<140/90mmHg(B),LDL 胆固醇目标定义为<100mg/dL(C)。ABC 控制定义为同时满足血糖、血压和 LDL 胆固醇目标的个体比例。我们还进行了多因素逻辑回归分析,以评估影响糖尿病治疗目标实现的因素。

结果

2008 年 10 月 18 日至 2020 年 12 月 17 日期间,共有 113043 人(城市地区 33537 人,农村地区 79506 人)参加了 ICMR-INDIAB 研究。在此分析中,5789 名患有自我报告糖尿病的成年人(城市地区 2633 人,农村地区 3156 人)被纳入研究人群。中位年龄为 56.1 岁(IQR 55.7-56.5)。总体而言,4834 名糖尿病患者中有 1748 人(加权比例 36.3%,95%CI 34.7-37.9)达到良好的血糖控制,5698 名患者中有 2819 人(加权比例 48.8%,47.2-50.3)达到血压控制,4886 名患者中有 2043 人(加权比例 41.5%,39.9-43.1)达到良好的 LDL 胆固醇控制。仅有 5297 名患有自我报告糖尿病的人中的 419 人(加权比例 7.7%)达到了所有三个 ABC 目标,各地区和各州之间存在显著差异。较高的教育程度、男性、农村居住和较短的糖尿病病程(<10 年)与更好地实现联合 ABC 目标相关。只有 951 名(加权比例 16.7%)的研究人群和 227 名(加权比例 36.9%)接受胰岛素治疗的患者报告使用了自我监测血糖。

结论

在印度,治疗目标的实现和健康行为的采用仍然不理想。我们的研究结果可以帮助政府采取政策,优先改善印度的糖尿病治疗服务和监测。

资金

印度医学研究理事会和印度卫生部、家庭福利部的健康研究部。

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