Miwa Toru, Okano Takayuki
Department of Otolaryngology-Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Department of Otolaryngology-Head and Neck Surgery, Tazuke Kofukai Medical Research Institute Kitano Hospital, Osaka, Japan.
Front Neurol. 2022 Apr 6;13:861992. doi: 10.3389/fneur.2022.861992. eCollection 2022.
Macrophages play important roles in tissue homeostasis and inflammation. Recent studies have revealed that macrophages are dispersed in the inner ear and may play essential roles in eliciting an immune response. Autoinflammatory diseases comprise a family of immune-mediated diseases, some of which involve sensorineural hearing loss, indicating that similar mechanisms may underlie the pathogenesis of immune-mediated hearing loss. Autoimmune inner ear disease (AIED) is an idiopathic disorder characterized by unexpected hearing loss. Tissue macrophages in the inner ear represent a potential target for modulation of the local immune response in patients with AIED/autoinflammatory diseases. In this review, we describe the relationship between cochlear macrophages and the pathophysiology of AIED/autoinflammatory disease.
巨噬细胞在组织稳态和炎症中发挥着重要作用。最近的研究表明，巨噬细胞分散在内耳中，可能在引发免疫反应中起关键作用。自身炎症性疾病是一类免疫介导的疾病，其中一些涉及感音神经性听力损失，这表明类似的机制可能是免疫介导性听力损失发病机制的基础。自身免疫性内耳疾病（AIED）是一种以突发性听力损失为特征的特发性疾病。内耳中的组织巨噬细胞是AIED/自身炎症性疾病患者局部免疫反应调节的潜在靶点。在这篇综述中，我们描述了耳蜗巨噬细胞与AIED/自身炎症性疾病病理生理学之间的关系。
