海洋红酵母 Rhodosporidium paludigenum 对早期断奶羔羊腹泻率、血清抗氧化能力、肠道免疫能力和微生物结构的影响。
Effect of Marine Red Yeast Rhodosporidium paludigenum on Diarrhea Rate, Serum Antioxidant Competence, Intestinal Immune Capacity, and Microflora Structure in Early-Weaned Lambs.
机构信息
Shihezi University, Shihezi, China.
Xinjiang Agricultural University, Wulumuqi, China.
出版信息
Biomed Res Int. 2022 Apr 15;2022:2228632. doi: 10.1155/2022/2228632. eCollection 2022.
In this study, the influences of marine red yeast Rhodosporidium paludigenum (MRYP) on diarrhea rate, serum antioxidant capacity, intestinal immunity capacity, and microflora structure of early-weaned lamb were investigated in a 60-day feeding trial. A total of 96 early-weaned lambs were utilized in this study. The lambs were divided into four experimental groups based on the percentage of marine red yeast Rhodosporidium paludigenum (MRYP) as milk replacer supplement. The rates of milk replacer supplement for the four groups were 0, 0.1%, 0.3%, and 0.5% of marine red yeast Rhodosporidium paludigenum (MRYP), respectively. The study was continued for 30 days. The results showed that (1) compared with control group, 0.5% marine red yeast Rhodosporidium paludigenum (MRYP) supplementation caused significantly decreases in average fecal score and diarrhea frequency by 33.74% and 40.23% ( < 0.05). (2) No significant difference was found in all tested related antioxidant indexes in serum of four treatments ( > 0.05). (3) The concentrations of SIgA, IgG, and IL-10 of group IV was significantly increased by 17.78%, 18.27%, and 8.17%, but the IL-6 and TNF- were significantly decreased by 21.20% and 31.80%, compared to group I in the colon ( < 0.05). (4) The number of and of group IV was significantly increased by 14.87% and 15.09%, but and were significantly decreased by 20.19% and 10.15%, compared to group I in the colon ( < 0.05). (5) A portion of marine red yeast Rhodosporidium paludigenum (MRYP) survived in the intestine of early-weaned lamb, and the number of survival marine red yeast Rhodosporidium paludigenum (MRYP) increased as the addition of marine red yeast Rhodosporidium paludigenum (MRYP) increased from 0.1 to 0.5% in milk replacer. Therefore, marine red yeast Rhodosporidium paludigenum (MRYP) has a potential to be a replacer of antibiotics for prevention and treatment of diarrhea in early-weaned lambs.
在这项研究中，通过 60 天的饲养试验，研究了海洋红酵母 Rhodosporidium paludigenum（MRYP）对断奶羔羊腹泻率、血清抗氧化能力、肠道免疫能力和微生物区系结构的影响。本研究共使用了 96 只断奶羔羊。根据海洋红酵母 Rhodosporidium paludigenum（MRYP）作为代乳料补充物的百分比，将羔羊分为四个实验组。四组代乳料补充物的海洋红酵母 Rhodosporidium paludigenum（MRYP）的比例分别为 0、0.1%、0.3%和 0.5%。研究持续了 30 天。结果表明：（1）与对照组相比，0.5%海洋红酵母 Rhodosporidium paludigenum（MRYP）补充剂使平均粪便评分和腹泻频率分别降低了 33.74%和 40.23%（<0.05）。（2）四组处理血清中所有测试的相关抗氧化指标均无显著差异（>0.05）。（3）与 I 组相比，IV 组的 SIgA、IgG 和 IL-10 浓度分别显著增加了 17.78%、18.27%和 8.17%，但 IL-6 和 TNF-α分别显著降低了 21.20%和 31.80%（<0.05）。（4）与 I 组相比，IV 组的 和 的数量分别显著增加了 14.87%和 15.09%，但 和 的数量分别显著减少了 20.19%和 10.15%（<0.05）。（5）一部分海洋红酵母 Rhodosporidium paludigenum（MRYP）在断奶羔羊的肠道中存活，随着代乳料中海洋红酵母 Rhodosporidium paludigenum（MRYP）添加量从 0.1%增加到 0.5%，存活的海洋红酵母 Rhodosporidium paludigenum（MRYP）数量增加。因此，海洋红酵母 Rhodosporidium paludigenum（MRYP）有可能成为预防和治疗断奶羔羊腹泻的抗生素替代品。
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