Fortuoso Bruno F, Gebert Roger R, Griss Luiz G, Glombovisky Patricia, Cazarotto Chrystian J, Rampazzo Luana, Stefani Lenita M, Ferreira Emanuel B, da Silva Aleksandro Schafer
Department of Animal Science, Universidade do Estado de Santa Catarina (UDESC), Brazil.
Graduate Program in Animal Science, UDESC, Brazil.
Microb Pathog. 2019 Feb;127:347-351. doi: 10.1016/j.micpath.2018.12.022. Epub 2018 Dec 13.
Lamb farming is generally a secondary activity for farmers, and many breeding systems suffer from management failures that impair production. One reason for decline in performance is enteritis, usually affecting newborn lambs. Enteritis can be fatal, especially in dairy herds. Generally, lambs are fed sucrose or unprocessed milk from sheep or cow that is heated and fed to animals two or three times a day in baby bottles. However, on most farms, milk temperature differs among feeds, as often the process of alteration among diet adaptations is deficient, contributing to enteritis and consequent diarrhea. Therefore, the objective of the present study was to verify the administration of the homeopathic product (Dia 100) in newborn and bottle-fed lambs, in order to prevent or minimize the occurrence of diarrhea. We studied 60 lambs, divided into two groups with ten repetitions each (n = 30) and during the nursing period (1-45 days of life). Animals in the treated group received the homeopathic product (36 g) orally divided into three doses (1, 7 and 14 days of life). We measured weight gain, mortality, bacterial counts (Escherichia coli and total coliforms) in feces, hematological analysis (leukocytes, hematocrit, hemoglobin and erythrocytes) and biochemical analyses (glucose, triglycerides, cholesterol, albumin, globulin, urea and total protein) at four time-points. There were no differences in weight gain between groups (P > 0.05); however, there was a higher mortality rate in the control group (13%) than in the treated group (6%). E. coli counts were significantly higher in the stools of control group lambs on days 15 and 45 of the experiment (P < 0.05). Total leukocyte counts were greater in treated animals due to greater numbers of lymphocytes on day 15 of the experiment (P < 0.05). In the treated group, we found higher serum levels of total protein, urea (day 15), globulin and triglycerides (days 15 and 30). In the period of administration of the homeopathic product, there was substantial and significant reduction of cases of diarrhea (up to day 14); however, after this period, there were no difference between groups. Based on these results, we concluded that the homeopathic product had moderate efficacy in terms of control of diarrhea. The treated lambs made better use of nutrients, contributing to the development of their immune responses.
养羊通常是农民的一项次要活动，许多繁殖系统存在管理不善的问题，影响了生产。生产性能下降的一个原因是肠炎，通常影响新生羔羊。肠炎可能是致命的，尤其是在奶牛群中。一般来说，羔羊喂食蔗糖或未经加工的羊奶或牛奶，将其加热后用奶瓶每天喂动物两到三次。然而，在大多数农场，每次喂食的牛奶温度不同，因为饮食适应过程往往不足，导致肠炎和随之而来的腹泻。因此，本研究的目的是验证顺势疗法产品（Dia 100）对新生奶瓶喂养羔羊的给药效果，以预防或减少腹泻的发生。我们研究了60只羔羊，分为两组，每组重复10次（n = 30），研究期为哺乳期（出生后1 - 45天）。治疗组的动物在出生后第1、7和14天口服顺势疗法产品（36克），分三次给药。我们在四个时间点测量了体重增加、死亡率、粪便中的细菌计数（大肠杆菌和总大肠菌群）、血液学分析（白细胞、血细胞比容、血红蛋白和红细胞）以及生化分析（葡萄糖、甘油三酯、胆固醇、白蛋白、球蛋白、尿素和总蛋白）。两组之间体重增加没有差异（P > 0.05）；然而，对照组的死亡率（13%）高于治疗组（6%）。在实验的第15天和第45天，对照组羔羊粪便中的大肠杆菌计数显著更高（P < 0.05）。由于实验第15天淋巴细胞数量更多，治疗组动物的总白细胞计数更高（P < 0.05）。在治疗组中，我们发现总蛋白、尿素（第15天）、球蛋白和甘油三酯（第15天和第30天）的血清水平更高。在顺势疗法产品给药期间，腹泻病例大幅显著减少（至第14天）；然而，在此期间之后，两组之间没有差异。基于这些结果，我们得出结论，顺势疗法产品在控制腹泻方面具有中等疗效。治疗组的羔羊能更好地利用营养物质，有助于其免疫反应的发展。
