Department of Oral Medicine and Diagnostic Sciences, AlFarabi Colleges for Dentistry and Nursing, Riyadh, Saudi Arabia.
Department of Oral Medicine, Faculty of Dentistry, Sana'a University, Sana'a, Yemen.
Int J Dent Hyg. 2020 Feb;18(1):44-51. doi: 10.1111/idh.12393. Epub 2019 Mar 25.
The present systematic review assessed the efficacy of aloe vera mouthrinse on plaque and gingival inflammation.
A comprehensive search of PubMed, EMBASE, Scopus and Web of Science was conducted in February 2018 to identify all relevant studies using the following keywords: aloe vera, gingivitis, gingival inflammation, plaque-induced gingivitis, periodontal health and plaque control. The eligibility criteria were all randomized clinical trials that assessed the efficacy of aloe vera mouthrinse in comparison to chlorhexidine on plaque and gingivitis. The risk of bias of the included studies was assessed using the Cochrane risk of bias assessment tool.
Six randomized clinical trials comprising 1358 subjects were included in this systematic review. All included studies showed that aloe vera was effective in reducing plaque and gingival inflammation. Four studies found aloe vera as effective as chlorhexidine in reducing plaque scores, while two studies found chlorhexidine significantly more effective than aloe vera. With regard to gingival inflammation, three studies showed comparable results between aloe vera and chlorhexidine, while one study showed better results with chlorhexidine. Moreover, the results showed that aloe vera had no or very minimal side effects compared to chlorhexidine, which showed significant side effects including stains and altered taste sensation.
The available evidence remains inconclusive but suggests that aloe vera mouthwash is comparable to chlorhexidine in reducing gingival inflammation but inferior to chlorhexidine in reducing plaque. These findings are preliminary and further high-quality studies with adequate sample sizes are highly recommended.
本系统评价评估了芦荟漱口液对菌斑和牙龈炎症的疗效。
2018 年 2 月，我们通过检索 PubMed、EMBASE、Scopus 和 Web of Science，使用以下关键词，全面检索了所有相关研究：芦荟、牙龈炎、牙龈炎症、菌斑性牙龈炎、牙周健康和菌斑控制。纳入标准为所有评估芦荟漱口液与洗必泰相比在菌斑和牙龈炎疗效的随机临床试验。使用 Cochrane 偏倚风险评估工具评估纳入研究的偏倚风险。
本系统评价纳入了 6 项随机临床试验，共 1358 名受试者。所有纳入的研究均表明，芦荟能有效减少菌斑和牙龈炎症。4 项研究发现，芦荟在减少菌斑评分方面与洗必泰同样有效，而 2 项研究发现洗必泰比芦荟更有效。关于牙龈炎症，3 项研究显示芦荟与洗必泰的结果相当，而 1 项研究显示洗必泰的效果更好。此外，结果表明，与洗必泰相比，芦荟几乎没有或仅有轻微的副作用，而洗必泰则显示出明显的副作用，包括染色和味觉改变。
现有证据尚无定论，但提示芦荟漱口水在减轻牙龈炎症方面与洗必泰相当，但在减少菌斑方面不如洗必泰。这些发现尚属初步，强烈建议开展进一步高质量、大样本量的研究。
