Amity Institute of Virology and Immunology, Amity University India, Noida, India.
Department of Zoology, Central University of Punjab, Bathinda, India.
Int J Cancer. 2022 Oct 1;151(7):981-992. doi: 10.1002/ijc.34060. Epub 2022 Jun 8.
Accumulating evidence demonstrates that the host genome's epigenetic modifications are essential for living organisms to adapt to extreme conditions. DNA methylation, covalent modifications of histone and interassociation of noncoding RNAs facilitate the cellular manifestation of epigenetic changes in the genome. Out of various factors involved in the epigenetic programming of the host, noncoding RNAs (ncRNAs) such as microRNA (miRNA), long noncoding RNA (lncRNA), circular RNA, snoRNA and piRNA are new generation noncoding molecules that influence a variety of cellular processes like immunity, cellular differentiation and tumor development. During tumor development, temporal changes in miRNA/lncRNA rheostat influence sterile inflammatory responses accompanied by the changes in the carcinogenic signaling in the host. At the cellular level, this is manifested by the upregulation of inflammasome and inflammatory pathways, which promotes cancer-related inflammation. Given this, we discuss the potential of lncRNAs, miRNAs, circular RNA, snoRNA and piRNA in regulating inflammation and tumor development in the host.
越来越多的证据表明，宿主基因组的表观遗传修饰对于生物适应极端环境至关重要。DNA 甲基化、组蛋白的共价修饰以及非编码 RNA 的相互作用促进了基因组中表观遗传变化的细胞表现。在宿主的表观遗传编程中涉及到许多因素，非编码 RNA（ncRNA），如 microRNA（miRNA）、长非编码 RNA（lncRNA）、环状 RNA、snoRNA 和 piRNA 是新一代非编码分子，影响着免疫、细胞分化和肿瘤发展等多种细胞过程。在肿瘤发展过程中，miRNA/lncRNA 变阻器的时间变化影响伴有宿主致癌信号变化的无菌炎症反应。在细胞水平上，这表现为炎性小体和炎症途径的上调，促进了与癌症相关的炎症。有鉴于此，我们讨论了 lncRNA、miRNA、环状 RNA、snoRNA 和 piRNA 在调节宿主炎症和肿瘤发展中的潜力。
