Department of Nutrition, Health Sciences Center, Federal University of Paraíba, Campus I - João Pessoa, Paraíba, Brazil.
Colegiado de Educação Física, Federal University of São Franscisco Valley, Petrolina, Brazil.
Probiotics Antimicrob Proteins. 2022 Oct;14(5):960-979. doi: 10.1007/s12602-022-09943-3. Epub 2022 Apr 25.
The unbalance in the production and removal of oxygen-reactive species in the human organism leads to oxidative stress, a physiological condition commonly linked to the occurrence of cancer, neurodegenerative, inflammatory, and metabolic disorders. The implications of oxidative stress in the gut have been associated with gut microbiota impairments and gut dysbiosis. Some lactobacilli strains have shown an efficient antioxidant system capable of protecting against oxidative stress and related-chronic diseases. Recently, in vitro and experimental studies and some clinical trials have demonstrated the efficacy of the administration of various Limosilactobacillus fermentum strains to modulate beneficially the host antioxidant system resulting in the amelioration of a variety of systemic diseases phenotypes. This review presents and discusses the currently available studies on identifying L. fermentum strains with anti-oxidant properties, their sources, range of the administered doses, and duration of the intervention in experiments with animals and clinical trials. This review strives to serve as a relevant and well-cataloged reference of L. fermentum strains with capabilities of inducing anti-oxidant effects and health-promoting benefits to the host, envisaging their broad applicability to disease control.
在人体中，活性氧的产生和清除之间的失衡会导致氧化应激，这是一种与癌症、神经退行性疾病、炎症和代谢紊乱等发生有关的生理状态。氧化应激在肠道中的影响与肠道微生物群的损伤和肠道菌群失调有关。一些乳杆菌菌株表现出有效的抗氧化系统，能够抵御氧化应激和相关的慢性疾病。最近，体外和实验研究以及一些临床试验已经证明了给予各种发酵乳杆菌菌株的有效性，可以有益地调节宿主的抗氧化系统，从而改善各种全身性疾病的表型。本综述介绍并讨论了目前关于鉴定具有抗氧化特性的发酵乳杆菌菌株的研究，包括它们的来源、给予剂量的范围、干预实验中动物和临床试验的持续时间。本综述旨在作为具有诱导抗氧化作用和对宿主健康促进作用的发酵乳杆菌菌株的相关且编目良好的参考，预计它们将广泛应用于疾病控制。
