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JL-3 从“江水”中分离得到，可通过降解尿酸来改善高尿酸血症。

JL-3 isolated from "Jiangshui" ameliorates hyperuricemia by degrading uric acid.

机构信息

Gansu Key Laboratory of Biomonitoring and Bioremediation for Environmental Pollution, School of Life Sciences, Lanzhou University, Lanzhou, China.

Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Science, Lanzhou University, Lanzhou, China.

出版信息

Gut Microbes. 2021 Jan-Dec;13(1):1-18. doi: 10.1080/19490976.2021.1897211.

DOI:10.1080/19490976.2021.1897211
PMID:33764849
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8007157/
Abstract

Recent studies into the beneficial effects of fermented foods have shown that this class of foods are effective in managing hyperuricemia and gout. In this study, the uric acid (UA) degradation ability of JL-3 strain, isolated from "Jiangshui" (a fermented Chinese food), was investigated. results showed that JL-3 strain exhibited high degradation capacity and selectivity toward UA. After oral administration to mice for 15 days, JL-3 colonization was continuously detected in the feces of mice. The UA level in urine of mice fed with JL-3 was similar with the control group mice. And the serum UA level of the former was significantly lower (31.3%) than in the control, further confirmed the UA-lowering effect of JL-3 strain. JL-3 strain also restored some of the inflammatory markers and oxidative stress indicators (IL-1β, MDA, CRE, blood urea nitrogen) related to hyperuricemia, while the gut microbial diversity results showed that JL-3 could regulate gut microbiota dysbiosis caused by hyperuricemia. Therefore, the probiotic JL-3 strain is effective in lowering UA levels in mice and could be used as a therapeutic adjunct agent in treating hyperuricemia.

摘要

最近对发酵食品有益作用的研究表明，这类食品在控制高尿酸血症和痛风方面非常有效。在这项研究中，从“Jiangshui”（一种发酵的中国食品）中分离出的 JL-3 菌株对尿酸（UA）的降解能力进行了研究。结果表明，JL-3 菌株对 UA 具有很高的降解能力和选择性。将 JL-3 菌株灌胃给小鼠 15 天后，在小鼠粪便中持续检测到 JL-3 定植。用 JL-3 喂养的小鼠尿液中的 UA 水平与对照组相似，而前者的血清 UA 水平明显降低（31.3%），进一步证实了 JL-3 菌株的降 UA 作用。JL-3 菌株还恢复了一些与高尿酸血症相关的炎症标志物和氧化应激指标（IL-1β、MDA、CRE、血尿素氮），而肠道微生物多样性结果表明，JL-3 可以调节高尿酸血症引起的肠道微生物失调。因此，益生菌 JL-3 菌株可有效降低小鼠的 UA 水平，可作为治疗高尿酸血症的辅助治疗剂。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a48/8007157/cd913b6e190a/KGMI_A_1897211_F0005_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a48/8007157/64e9fe572a35/KGMI_A_1897211_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a48/8007157/e07d661701d9/KGMI_A_1897211_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a48/8007157/3073a5abbae4/KGMI_A_1897211_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a48/8007157/d2dbb5b234ae/KGMI_A_1897211_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a48/8007157/cd913b6e190a/KGMI_A_1897211_F0005_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a48/8007157/64e9fe572a35/KGMI_A_1897211_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a48/8007157/e07d661701d9/KGMI_A_1897211_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a48/8007157/3073a5abbae4/KGMI_A_1897211_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a48/8007157/d2dbb5b234ae/KGMI_A_1897211_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a48/8007157/cd913b6e190a/KGMI_A_1897211_F0005_OC.jpg

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