HIV 感染的血液生物标志物——关注神经并发症——综述。
Blood biomarkers for HIV infection with focus on neurologic complications-A review.
机构信息
Department of Infectious Diseases, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Region Västra Götaland, Sahlgrenska University Hospital, Gothenburg, Sweden.
出版信息
Acta Neurol Scand. 2022 Jul;146(1):56-60. doi: 10.1111/ane.13629. Epub 2022 Apr 26.
Abstract
Although clinical examinations, neuroimaging, and cerebrospinal fluid analyses are the most important ways to evaluate the impact of HIV infection on the brain and in diagnosis of opportunistic infections, several blood biomarkers including HIV RNA concentrations, CD4 +T-cell count, and neurofilament light chain protein (NfL) concentration, along with tests for opportunistic infections can provide important information for clinical decisions.
摘要
虽然临床检查、神经影像学和脑脊液分析是评估 HIV 感染对大脑影响和诊断机会性感染的最重要方法，但包括 HIV RNA 浓度、CD4+T 细胞计数和神经丝轻链蛋白（NfL）浓度在内的几种血液生物标志物，以及机会性感染的检测，可以为临床决策提供重要信息。
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