Dong Yipeng, Zhang Mingshan, Han Daobo, Deng Zhichao, Cao Xuewei, Tian Jianguo, Ye Qing
Key Laboratory of Weak-Light Nonlinear Photonics, Ministry of Education, School of Physics and TEDA Applied Physics, Nankai University, Tianjin 300071, P. R. China.
Nankai University Eye Institute, Nankai University Afflicted Eye Hospital, Nankai University, Tianjin, China.
J Mater Chem B. 2022 May 25;10(20):3906-3915. doi: 10.1039/d2tb00330a.
Gelatin methacryloyl (GelMA) is a popular photocrosslinkable hydrogel that has been widely utilized in tissue engineering and regenerative medicine fields due to its excellent biocompatibility, biodegradability and cell response. However, the lack of mechanical properties limits its application. In the present study, a method for the preparation of a GelMA-GelMA (G-G) homogeneous double-network (DN) hydrogel to improve mechanical strength based on DLP 3D printing is proposed. The G-G DN hydrogel was fabricated and characterized in terms of microstructure, mechanical properties and rheological behavior. By modifying the degree of substitution (DS), the polymer concentration of double network crosslinking and the soak time, the novel G-G DN hydrogel could significantly improve the properties of strength, self-recovery and fatigue resistance. After all, the novel porous composite hydrogel (G-G DN hydrogel) could achieve more than twice that of the pure GelMA hydrogel, better fatigue resistance and printable ability. Therefore, it can be a potential choice of applications attracting great attention for its mechanical properties, great transmittance and biocompatibility.
甲基丙烯酰化明胶（GelMA）是一种广受欢迎的可光交联水凝胶，因其优异的生物相容性、生物降解性和细胞反应性，已在组织工程和再生医学领域得到广泛应用。然而，其机械性能的不足限制了它的应用。在本研究中，提出了一种基于数字光处理（DLP）3D打印制备GelMA-GelMA（G-G）均质双网络（DN）水凝胶以提高机械强度的方法。对G-G DN水凝胶进行了制备，并对其微观结构、机械性能和流变行为进行了表征。通过改变取代度（DS）、双网络交联的聚合物浓度和浸泡时间，新型G-G DN水凝胶可显著提高强度、自恢复和抗疲劳性能。毕竟，新型多孔复合水凝胶（G-G DN水凝胶）的性能可达到纯GelMA水凝胶的两倍以上，具有更好的抗疲劳性和可打印性。因此，因其机械性能、良好、高透光率和生物相容性，它可能成为备受关注的潜在应用选择。
