Department of Psychiatry and Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada.
Krembil Centre for Neuroinformatics, Centre for Addiction and Mental Health, Toronto, ON, Canada.
Adv Exp Med Biol. 2022;1359:313-355. doi: 10.1007/978-3-030-89439-9_13.
Whole-Brain Modelling is a scientific field with a short history and a long past. Its various disciplinary roots and conceptual ingredients extend back to as early as the 1940s. It was not until the late 2000s, however, that a nascent paradigm emerged in roughly its current form-concurrently, and in many ways joined at the hip, with its sister field of macro-connectomics. This period saw a handful of seminal papers authored by a certain motley crew of notable theoretical and cognitive neuroscientists, which have served to define much of the landscape of whole-brain modelling as it stands at the start of the 2020s. At the same time, the field has over the past decade expanded in a dozen or more fascinating new methodological, theoretical, and clinical directions. In this chapter we offer a potted Past, Present, and Future of whole-brain modelling, noting what we take to be some of its greatest successes, hardest challenges, and most exciting opportunities.
全脑建模是一个历史短暂但渊源流长的科学领域。它的各种学科根源和概念成分可以追溯到 20 世纪 40 年代早期。直到 2000 年代后期，一种新兴的范式才以大致目前的形式出现——与宏观连接组学领域同时出现，并在许多方面紧密结合。这一时期出现了少数几篇由一群著名的理论和认知神经科学家撰写的开创性论文，这些论文定义了 21 世纪 20 年代初全脑建模的大部分领域。与此同时，该领域在过去十年中以十多个迷人的新方法学、理论和临床方向扩展。在本章中，我们提供了全脑建模的简史、现状和未来，指出了我们认为它最成功、最具挑战性和最令人兴奋的一些机会。
