Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee, USA.
Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Vanderbilt University, Nashville, Tennessee, USA.
Obesity (Silver Spring). 2022 Jun;30(6):1257-1267. doi: 10.1002/oby.23408. Epub 2022 Apr 26.
This study aimed to investigate whether and how lipid peroxidation markers are associated with height and obesity measures.
In two independent samples of women (Study 1: n = 1,005; Study 2: n = 1,158), systemic levels of lipid peroxidation were assessed by urinary markers F -isoprostanes (F -IsoPs) and its major metabolite (F -IsoP-M), with gas chromatography/negative ion chemical ionization mass spectrometry assays. Anthropometric parameters were directly measured and genetically estimated, and they were used in the primary analysis and in a Mendelian randomization analysis in relation to lipid peroxidation, respectively, with general linear models.
After adjusting for potential confounders, it was found that measured adult height was inversely associated with levels of F -IsoPs (β = -0.89, p < 0.001) and F -IsoP-M (β = -0.71, p = 0.003), whereas obesity measures were positively associated with F -IsoP-M (β = 1.81, p < 0.001 for BMI; and β = 0.77, p < 0.001 for waist circumference). Results were consistent between the two study samples. The opposite associations were further replicated when using genetically determined measures of height and obesity in the Mendelian randomization analysis. Moreover, analyses mutually adjusted for height and obesity measures suggested that these associations were independent of one another.
This study, for the first time, to our knowledge, reveals that a shared biological process (lipid peroxidation) is associated with both height and obesity measures but in the opposite direction.
本研究旨在探讨脂质过氧化标志物与身高和肥胖指标的关系，以及这种关系是否存在。
在两个独立的女性样本中（研究 1：n=1005；研究 2：n=1158），采用气相色谱/负离子化学电离质谱法检测尿液中脂质过氧化标志物 F -异前列腺素（F -IsoPs）及其主要代谢产物（F -IsoP-M）来评估全身脂质过氧化水平。直接测量和遗传估计了人体测量参数，并分别使用一般线性模型在原发性分析和与脂质过氧化相关的孟德尔随机化分析中使用这些参数。
在调整了潜在混杂因素后，发现成人身高与 F -IsoPs（β=-0.89，p<0.001）和 F -IsoP-M（β=-0.71，p=0.003）水平呈负相关，而肥胖指标与 F -IsoP-M 呈正相关（β=1.81，BMI 时 p<0.001；β=0.77，腰围时 p<0.001）。这两个研究样本的结果是一致的。在孟德尔随机化分析中，当使用遗传确定的身高和肥胖指标时，结果得到了进一步的验证。此外，相互调整身高和肥胖指标的分析表明，这些关联是相互独立的。
本研究首次表明，一个共同的生物学过程（脂质过氧化）与身高和肥胖指标相关，但方向相反。
