利用贯叶连翘和牛至提取物及其主要成分金丝桃素和香芹酚合成二氧化钛纳米粒子，作为有前途的抗菌剂。
Biosynthesis of titanium dioxide nanoparticles using Hypericum perforatum and Origanum vulgare extracts and their main components, hypericin and carvacrol as promising antibacterial agents.
机构信息
Department of Physiology and Pharmacology, School of Medicine, Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran.
Biotechnology and Medicinal Plants Research Center, Ilam University of Medical Sciences, Ilam, Iran.
出版信息
J Tradit Chin Med. 2022 Apr;42(2):167-175. doi: 10.19852/j.cnki.jtcm.2022.02.002.
OBJECTIVE
To evaluate the anti-bacterial activities of titanium dioxide (TiO) nanoparticles of Origanum (O.) vulgare and Hypericum (H.) perforatum extracts, carvacrol and hypericin against Staphylococcus (S.) aureus.
METHODS
In this study, TiOnanoparticles of O. vulgare and H. perforatum extracts, carvacrol and hypericin, were prepared and their antibacterial effects were evaluated against Staphylococcus (S.) aureus. In this study, scanning electron microscope, fourier transform infrared spectrometer, atomic force microscopy, dynamic light scattering and zeta potential were used to investigate the structure of synthesized drugs.
RESULTS
Anti-bacterial activity of synthesized NPs was tested by minimum inhibitory concentration (MIC), minimum bactericidal concentration and disc diffusion method. MICs of TiO-NPs synthesized using O. vulgare, H. perforatum, carvacrol and hypericin and TiO were obtained 250, 62.5, 250, and 250, and 500 μg/mL, respectively. The MBCs for all of these were obtained 1000 μg/mL.
CONCLUSION
Green-synthesized of TiO nanoparticles provides a promising approach to the use of O. vulgare and H. perforatum, carvacrol and hypericin as novel agents and safer antibacterial compounds, especially anti-S. aureus compounds.
目的
评估牛至（O. vulgare）和贯叶连翘（H. perforatum）提取物、香芹酚和金丝桃素的二氧化钛（TiO ）纳米粒子对金黄色葡萄球菌（S. aureus）的抗菌活性。
方法
本研究制备了牛至和贯叶连翘提取物、香芹酚和金丝桃素的 TiO 纳米粒子，并评价了它们对金黄色葡萄球菌的抗菌作用。在本研究中，使用扫描电子显微镜、傅里叶变换红外光谱仪、原子力显微镜、动态光散射和zeta 电位研究了合成药物的结构。
结果
通过最低抑菌浓度（MIC）、最低杀菌浓度和圆盘扩散法测试了合成 NPs 的抗菌活性。使用牛至、贯叶连翘、香芹酚和金丝桃素以及 TiO 合成的 TiO-NPs 的 MIC 分别为 250、62.5、250 和 250μg/mL，以及 500μg/mL。所有这些的 MBC 均为 1000μg/mL。
结论
TiO 纳米粒子的绿色合成为牛至和贯叶连翘、香芹酚和金丝桃素作为新型抗菌剂和更安全的抗菌化合物的使用提供了有前途的方法，特别是抗金黄色葡萄球菌化合物。
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