Kevrekidou Alkistis, Goutzourelas Nikolaos, Savvidi Stavroula, Trachana Varvara, Assimopoulou Andreana N, Liu Ming, Malea Paraskevi, Stagos Dimitrios
Laboratory of Organic Chemistry, School of Chemical Engineering, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
Department of Biochemistry and Biotechnology, School of Health Sciences, University of Thessaly, Biopolis, 41500 Larissa, Greece.
Molecules. 2025 Jun 29;30(13):2800. doi: 10.3390/molecules30132800.
Bioactive extracts from living plants (LR) and beach deposits (NR) of the submerged brackish water angiosperm were examined for their antioxidant activity and anticancer potential. LR extract scavenged effectively free radicals with IC values of 38.00 μg/mL (DPPH), 12.00 μg/mL (ABTS), 281.00 μg/mL (OH), and 53.00 μg/mL (O), and exhibited reducing activity with an RP value of 37.00 μg/mL. NR extract retained a significant part of LR extract's antioxidant activity by scavenging free radicals with IC values of 180.00 μg/mL (DPPH), 60.00 μg/mL (ABTS), and 164.00 μg/mL (O), and exhibited reducing activity with an RP value of 107.00 μg/mL. Importantly, NR extract (IC value: 60.00 μg/mL) exhibited much higher inhibitory activity than LR extract (IC value: 1100.00 μg/mL) in XTT assay. HPLC analysis revealed that both extracts contained phenolics, such as chicoric acid, quercetin-3--glucopyranoside, -coumaric acid, 3,5-dimethoxy-4-hydroxicinnanic acid, -ferulic acid, and rutin hydrate, possessing antioxidant and/or anticancer activity. Thus, the present study showed for the first time that extracts from either LR or NR are a promising source of bioactive compounds having beneficial properties for human health.
对生长在半咸水淹没环境中的被子植物的活体植物提取物（LR）和海滩沉积物提取物（NR）进行了抗氧化活性和抗癌潜力检测。LR提取物能有效清除自由基，其清除DPPH自由基的IC值为38.00 μg/mL、ABTS自由基的IC值为12.00 μg/mL、OH自由基的IC值为281.00 μg/mL、O自由基的IC值为53.00 μg/mL，并表现出还原活性，其RP值为37.00 μg/mL。NR提取物通过清除自由基保留了LR提取物抗氧化活性的很大一部分，其清除DPPH自由基的IC值为180.00 μg/mL、ABTS自由基的IC值为60.00 μg/mL、O自由基的IC值为164.00 μg/mL，并表现出还原活性，其RP值为107.00 μg/mL。重要的是，在XTT检测中，NR提取物（IC值：60.00 μg/mL）比LR提取物（IC值：1100.00 μg/mL）表现出更高的抑制活性。高效液相色谱分析表明，两种提取物均含有酚类物质，如菊苣酸、槲皮素-3-O-葡萄糖苷、对香豆酸、3,5-二甲氧基-4-羟基肉桂酸、阿魏酸和水合芦丁，这些物质具有抗氧化和/或抗癌活性。因此，本研究首次表明，LR或NR提取物都是具有对人类健康有益特性的生物活性化合物的有前途的来源。
