人卵泡液中的促性腺激素释放肽：分离、特性鉴定及化学合成
Gonadotropin-releasing peptide from human follicular fluid: isolation, characterization, and chemical synthesis.
作者信息
Li C H, Ramasharma K, Yamashiro D, Chung D
出版信息
Proc Natl Acad Sci U S A. 1987 Feb;84(4):959-62. doi: 10.1073/pnas.84.4.959.
Abstract
A gonadotropin-releasing peptide has been isolated from human follicular fluid. Its amino acid composition and sequence are completely different from the hypothalamic lutropin-releasing hormone. It is designated human follicular gonadotropin-releasing peptide and abbreviated as hF-GRP. The primary structure of this peptide (H-Thr-Asp-Thr-Ser-His-His-Asp-Gln-Asp-His-Pro-Thr-Phe-Asn-OH) has been confirmed by chemical synthesis. In the mouse pituitary incubation assay, the ED50 value for follitropin or lutropin release is estimated to be 1.2-1.6 nM.
摘要
一种促性腺激素释放肽已从人卵泡液中分离出来。其氨基酸组成和序列与下丘脑促黄体生成素释放激素完全不同。它被命名为人卵泡促性腺激素释放肽，简称为hF-GRP。该肽的一级结构（H-苏氨酸-天冬氨酸-苏氨酸-丝氨酸-组氨酸-组氨酸-天冬氨酸-谷氨酰胺-天冬氨酸-组氨酸-脯氨酸-苏氨酸-苯丙氨酸-天冬酰胺-OH）已通过化学合成得到证实。在小鼠垂体孵育试验中，促卵泡素或促黄体生成素释放的半数有效剂量（ED50）值估计为1.2 - 1.6 nM。
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