Department of Food and Nutrition, Andong National University, Andong 760-749, South Korea.
Department of Horticulture and Breeding, Andong National University, Andong 760-749, South Korea.
Mol Nutr Food Res. 2022 Jul;66(13):e2101049. doi: 10.1002/mnfr.202101049. Epub 2022 May 24.
Inflammatory bowel disease (IBD), including ulcerative colitis (UC), is a chronic recurrent inflammatory disease of the digestive tract and increases the risk of colon cancer.
This study evaluates the effects of dietary intervention with freeze-dried plum (FDP), a natural antioxidant and anti-inflammatory fruit with no toxicity on dextran sulfate sodium (DSS)-induced acute and chronic experimental colitis in a mouse model and studies the molecular mechanisms of protection through the gut-liver axis. The results show that FDP decreases the levels of inflammatory mediators, which is a nitrative stress biomarker in both acute and chronic models. FDP markedly reduces DSS-induced injury to the colonic epithelium in both acute and chronic models. In addition, FDP significantly decreases the levels of pro-oxidant markers such as CYP2E1, iNOS, and nitrated proteins (detected by anti-3-NT antibody) in DSS-induced acute and chronic colonic injury models. Furthermore, FDP markedly reduces markers of liver injury such as serum ALT/AST, antioxidant markers, and inflammatory mediators in DSS-induced acute and chronic colonic injury.
These results demonstrate that the FDP exhibits a protective effect on DSS-induced acute and chronic colonic and liver injury through the gut-liver axis via antioxidant and anti-inflammatory properties.
炎症性肠病（IBD），包括溃疡性结肠炎（UC），是一种慢性复发性消化道炎症性疾病，增加了结肠癌的风险。
本研究评估了冻干李（FDP）饮食干预对葡聚糖硫酸钠（DSS）诱导的急性和慢性实验性结肠炎模型中肠道-肝脏轴的影响，FDP 是一种天然抗氧化剂和抗炎性水果，无毒性。研究结果表明，FDP 可降低两种模型中促炎介质的水平，这是一种硝化应激生物标志物。FDP 可显著减轻两种模型中 DSS 诱导的结肠上皮损伤。此外，FDP 可显著降低 DSS 诱导的急性和慢性结肠损伤模型中促氧化剂标志物的水平，如 CYP2E1、iNOS 和硝化蛋白（用抗 3-NT 抗体检测）。此外，FDP 可显著降低 DSS 诱导的急性和慢性结肠损伤模型中肝损伤标志物，如血清 ALT/AST、抗氧化标志物和炎症介质的水平。
这些结果表明，FDP 通过抗氧化和抗炎特性，通过肠道-肝脏轴对 DSS 诱导的急性和慢性结肠和肝脏损伤表现出保护作用。
