乳腺癌患者使用单克隆抗体针对潜伏膜蛋白 1（LMP1）的 Epstein-Barr 病毒感染率。
Incidence of Epstein-Barr Virus Among Women With Breast Cancer Using Monoclonal Antibodies for Latent Membrane Protein 1 (LMP1).
机构信息
Department of Clinical Laboratory Science, College of Applied Medical Sciences, Taif University, Taif, Kingdom of Saudi Arabia;
Faculty of Medical Laboratory Science, Histopathology Department, Al Neelain University, Coralville, IA, U.S.A.
出版信息
In Vivo. 2022 May-Jun;36(3):1513-1518. doi: 10.21873/invivo.12860.
BACKGROUND/AIM: Breast cancer is a common type of cancer in Sudan. Numerous studies propose viral oncogenesis as an etiological factor for breast cancer. The aim of the study was to analyze the presence of the Epstein-Barr virus (EBV) using monoclonal antibodies against latent membrane protein 1 (LAMP1) and determine the correlation between the presence of EBV and clinicopathological characteristics.
PATIENTS AND METHODS
This study used immunohistochemistry to analyze the presence of EBV in 202 samples from Sudanese women diagnosed with breast cancer. Clinicopathological data were collected from patient records from the Radiation and Isotopes Centre in Khartoum State, Republic of Sudan.
RESULTS
This study included 202 patients 168 (83.2%), 16 (7.9%), and 18 (8.9%), diagnosed with invasive ductal carcinoma, invasive lobular carcinoma, and papillary carcinoma, respectively. Axillary lymph node metastasis was present in 57 (28.2%) of cases, while 11 patients (5.4%) tested positive for EBV. The mean age of patients was 48.14±14.4 years. EBV infection was more frequently detected in invasive ductal carcinoma cases, and EBV positivity was not associated with cancer type, grade, progesterone levels, and HER2 expression. On the other hand, a statistically significant association was found between EBV presence and lymph node involvement, estrogen receptor status, and age group.
CONCLUSION
EBV may not play a vital role in the pathogenesis of breast carcinoma in Sudanese women.
背景/目的：乳腺癌是苏丹常见的癌症类型。许多研究提出病毒致癌作用是乳腺癌的病因之一。本研究旨在使用针对潜伏膜蛋白 1（LAMP1）的单克隆抗体分析 Epstein-Barr 病毒（EBV）的存在，并确定 EBV 的存在与临床病理特征之间的相关性。
患者和方法
本研究使用免疫组织化学分析了来自苏丹妇女的 202 个乳腺癌诊断样本中 EBV 的存在。临床病理数据来自苏丹共和国喀土穆州辐射与同位素中心的患者记录。
结果
本研究包括 202 名患者，分别诊断为浸润性导管癌、浸润性小叶癌和乳头状癌的患者分别为 168 例（83.2%）、16 例（7.9%）和 18 例（8.9%）。57 例（28.2%）存在腋窝淋巴结转移，11 例（5.4%）患者 EBV 检测呈阳性。患者的平均年龄为 48.14±14.4 岁。EBV 感染在浸润性导管癌病例中更频繁地检测到，并且 EBV 阳性与癌症类型、分级、孕激素水平和 HER2 表达无关。另一方面，发现 EBV 存在与淋巴结受累、雌激素受体状态和年龄组之间存在统计学显著关联。
结论
EBV 可能在苏丹妇女乳腺癌的发病机制中不起重要作用。
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